{"doi":"10.1002/nbm.70194","title":"Validation of Dynamic Deuterium Metabolic Imaging (DMI) for the Measurement of Cerebral Metabolic Rates of Glucose in Rat","abstract":"ABSTRACT Deuterium metabolic imaging (DMI) is an innovative technique in which 2 H magnetic resonance spectroscopic imaging (MRSI) is utilized to determine the metabolic activity of administered 2 H‐labeled substrates. As such it can be viewed as the 2 H counterpart to more traditional 13 C labeling methods that can be considered the gold standard for metabolic mapping in vivo. To ensure reliable findings from dynamic 2 H MRSI experiments about absolute metabolic flux rates after administration of a 2 H‐labeled substrate it is essential to take into account 2 H‐specific aspects, namely 2 H label losses and kinetic isotopy effects (KIEs). Here, a modified version of a 13 C‐based metabolic model for glucose metabolism in rat brain was developed to address these 2 H‐related effects, tested for 2 H MRSI data acquired during infusion of [6,6'‐ 2 H 2 ]‐glucose, and validated by comparison with indirect 1 H‐[ 13 C] MRSI data acquired during infusion of [1‐ 13 C]‐glucose. The flux rates for glucose consumption (CMR gl = 0.57 ± 0.08 μmol/min/g) and the TCA cycle (V tca = 1.24 ± 0.14 μmol/min/g) derived from the 2 H MRSI data and using the updated metabolic model were in excellent agreement with the estimates based on 13 C data (CMR gl = 0.59 ± 0.14 μmol/min/g and V tca = 1.24 ± 0.32 μmol/min/g). The successful validation of dynamic 2 H MRSI for absolute flux rate determination forms the basis for future quantitative study of metabolic disorders in vivo.","journal":"NMR in Biomedicine","year":2025,"id":537498,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.954,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":994135,"name":"Monique Thomas","orcid":null,"position":1,"is_corresponding":false},{"id":298418,"name":"Graeme F. Mason","orcid":"0000-0002-6573-5222","position":2,"is_corresponding":false},{"id":262947,"name":"Robin A. de Graaf","orcid":"0000-0002-6570-7010","position":3,"is_corresponding":false},{"id":535240,"name":"Henk M. De Feyter","orcid":"0000-0001-6111-0316","position":4,"is_corresponding":false},{"id":1423301,"name":"Claudius Mathy","orcid":"0000-0002-6834-3355","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T02:52:12.997494Z","pmid":"41371621","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}