{"doi":"10.1002/nbm.4562","title":"Oxygen‐enhanced functional lung imaging using a contemporary 0.55 T MRI system","abstract":"Abstract The purpose of this study was to evaluate oxygen‐enhanced pulmonary imaging at 0.55 T with 3D stack‐of‐spirals ultrashort‐ T E (UTE) acquisition. Oxygen‐enhanced pulmonary MRI offers the measurement of regional lung ventilation and perfusion using inhaled oxygen as a contrast agent. Low‐field MRI systems equipped with contemporary hardware can provide high‐quality structural lung imaging by virtue of the prolonged T 2 *. Fortuitously, the T 1 relaxivity of oxygen increases at lower field strengths, which is expected to improve the sensitivity of oxygen‐enhanced lung MRI. We implemented a breath‐held T 1 ‐weighted 3D stack‐of‐spirals UTE acquisition with a 7 ms spiral‐out readout. Measurement repeatability was assessed using five repetitions of oxygen‐enhanced lung imaging in healthy volunteers ( n = 7). The signal intensity at both normoxia and hyperoxia was strongly dependent on lung tissue density modulated by breath‐hold volume during the five repetitions. A voxel‐wise correction for lung tissue density improved the repeatability of percent signal enhancement maps (coefficient of variation = 34 ± 16%). Percent signal enhancement maps were compared in 15 healthy volunteers and 10 patients with lymphangioleiomyomatosis (LAM), a rare cystic disease known to reduce pulmonary function. We measured a mean percent signal enhancement of 9.0 ± 3.5% at 0.55 T in healthy volunteers, and reduced signal enhancement in patients with LAM (5.4 ± 4.8%, p = 0.02). The heterogeneity, estimated by the percent of lung volume exhibiting low enhancement, was significantly increased in patients with LAM compared with healthy volunteers (11.1 ± 6.0% versus 30.5 ± 13.1%, p = 0.01), illustrating the capability to measure regional functional deficits.","journal":"NMR in Biomedicine","year":2021,"id":161031,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9608,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":329135,"name":"Rajiv Ramasawmy","orcid":"0000-0002-9821-9187","position":1,"is_corresponding":false},{"id":512515,"name":"Ahsan Javed","orcid":"0000-0003-1311-1247","position":2,"is_corresponding":false},{"id":235792,"name":"Marcus Y. Chen","orcid":"0000-0003-0743-9369","position":3,"is_corresponding":false},{"id":480638,"name":"Thomas Benkert","orcid":"0000-0002-3794-5580","position":4,"is_corresponding":false},{"id":671941,"name":"Waqas Majeed","orcid":"0000-0002-1280-0238","position":5,"is_corresponding":false},{"id":294247,"name":"Robert J. Lederman","orcid":"0000-0003-1202-6673","position":6,"is_corresponding":false},{"id":241249,"name":"Joel Moss","orcid":"0000-0003-1788-1927","position":7,"is_corresponding":false},{"id":675219,"name":"Robert S. Balaban","orcid":"0000-0003-4086-0948","position":8,"is_corresponding":false},{"id":280607,"name":"Adrienne Campbell‐Washburn","orcid":"0000-0002-7169-5693","position":9,"is_corresponding":false},{"id":675218,"name":"Ipshita Bhattacharya","orcid":"0000-0003-1976-5372","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-18T23:44:52.299342Z","pmid":"34080253","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}