{"doi":"10.1002/mrm.30562","title":"Magnitude preparation‐based MR‐acoustic radiation force imaging","abstract":"Abstract Purpose To visualize ultrasonic foci in tissue without phase subtraction, to reduce sensitivity to motion and respiration. A secondary purpose is to provide inherently fused anatomy and focus depiction across various image contrasts. Methods A magnitude‐contrast MR‐acoustic radiation force imaging (Mag‐ARFI) magnetization‐preparation sequence was implemented that converts displacement‐induced phase shifts into modulated longitudinal magnetization that can be read out by a subsequent imaging sequence. Phantom experiments compared focus visualization between conventional phase contrast‐ARFI and Mag‐ARFI, and demonstrated the ability to quantify displacement using multiple Mag‐ARFI measurements. In vivo phase contrast‐ARFI maps and ‐ and ‐weighted Mag‐ARFI images were acquired using a loop coil that was pulsed with DC to mimic an ultrasound focus‐induced phase shift. Breathing motion artifacts in head images were compared between the phase‐contrast MR‐ARFI and Mag‐ARFI methods. Results Phantom experiments demonstrated strong agreement (R = 0.88) between Mag‐ARFI and phase contrast‐ARFI displacement values. Mag‐ARFI and phase‐contrast ARFI peak displacements were 3.02 m and 3.91 m, respectively. Mag‐ARFI FWHM was [9.45, 10.35] mm, compared to phase contrast‐ARFI FWHM of [7.65, 8.56] mm. Head Mag‐ARFI images showed the focus fused with background anatomy, correlating well with phase contrast‐ARFI (R = 0.87 for T 1 ‐weighted, R = 0.79 for T 2 ‐weighted). Mag‐ARFI had reduced breathing motion artifacts, with 3.5 lower coefficient of variation than phase contrast‐ARFI. Conclusion Mag‐ARFI allows ultrasound focus localization, with reduced breathing motion artifacts, on ‐ and ‐weighted magnitude images containing background anatomical details.","journal":"Magnetic Resonance in Medicine","year":2025,"id":552998,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.957,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1433881,"name":"Kristen Zarcone","orcid":"0009-0008-8199-9691","position":1,"is_corresponding":false},{"id":497343,"name":"William A. Grissom","orcid":"0000-0002-3289-1827","position":2,"is_corresponding":false},{"id":1449303,"name":"Anuj Kumar Sharma","orcid":"0009-0001-2782-1242","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":null,"created_at":"2026-07-19T02:54:37.527189Z","pmid":"40443184","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}