{"doi":"10.1002/mrm.30090","title":"A vendor‐neutral EPI sequence for hyperpolarized <scp><sup>13</sup>C MRI</scp>","abstract":"Abstract Purpose To develop a flexible, vendor‐neutral EPI sequence for hyperpolarized 13 C metabolic imaging. Methods An open‐source EPI sequence consisting of a metabolite‐specific spectral‐spatial RF excitation pulse and a customizable EPI readout was created using the Pulseq framework. To explore the flexibility of our sequence, we tested several versions of the sequence including a symmetric 3D readout with different spatial resolutions for each metabolite (1.0 cm 3 and 1.5 cm 3 ). A multichamber phantom constructed with a Shepp‐Logan geometry, containing two chambers filled with either natural abundance 13 C compounds or hyperpolarized (HP) [1– 13 C]pyruvate, was used to test each sequence. For experiments involving HP [1– 13 C]pyruvate, a single chamber was prefilled with nicotinamide adenine dinucleotide hydride and lactate dehydrogenase to facilitate the conversion of [1– 13 C]pyruvate to [1– 13 C]lactate. All experiments were performed on a Siemens Prisma 3T scanner. Results All the sequence variations localized natural‐abundance 13 C ethylene glycol and methanol to the appropriate compartment of the multichamber phantom. [1– 13 C]pyruvate was detectable in both chambers following the injection of HP [1– 13 C]pyruvate, whereas [1– 13 C]lactate was only found in the chamber containing nicotinamide adenine dinucleotide hydride and lactate dehydrogenase. The conversion rate from [1– 13 C]pyruvate to [1– 13 C]lactate ( k PL ) was 0.01 s −1 (95% confidence interval [0.00, 0.02]). Conclusion We have developed and tested a vendor‐neutral EPI sequence for imaging HP 13 C agents. We have made all of our sequence creation and image reconstruction code freely available online for other investigators to use.","journal":"Magnetic Resonance in Medicine","year":2024,"id":479762,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9465,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":838864,"name":"Ashley Shaw","orcid":"0000-0001-7559-3224","position":1,"is_corresponding":false},{"id":401767,"name":"Cornelius von Morze","orcid":"0000-0002-3992-1793","position":2,"is_corresponding":false},{"id":401770,"name":"Tyler Blazey","orcid":"0000-0002-3402-0654","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T02:06:54.284166Z","pmid":"38525658","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}