{"doi":"10.1002/mrm.30077","title":"A <scp>3D</scp> dual‐echo spiral sequence for simultaneous <scp>dynamic susceptibility contrast</scp> and dynamic contrast‐enhanced <scp>MRI</scp> with single bolus injection","abstract":"PURPOSE: Perfusion MRI reveals important tumor physiological and pathophysiologic information, making it a critical component in managing brain tumor patients. This study aimed to develop a dual-echo 3D spiral technique with a single-bolus scheme to simultaneously acquire both dynamic susceptibility contrast (DSC) and dynamic contrast-enhanced (DCE) data and overcome the limitations of current EPI-based techniques. METHODS: A 3D spiral-based technique with dual-echo acquisition was implemented and optimized on a 3T MRI scanner with a spiral staircase trajectory and through-plane SENSE acceleration for improved speed and image quality, in-plane variable-density undersampling combined with a sliding-window acquisition and reconstruction approach for increased speed, and an advanced iterative deblurring algorithm. Four volunteers were scanned and compared with the standard of care (SOC) single-echo EPI and a dual-echo EPI technique. Two patients were scanned with the spiral technique during a preload bolus and compared with the SOC single-echo EPI collected during the second bolus injection. RESULTS: Volunteer data demonstrated that the spiral technique achieved high image quality, reduced geometric artifacts, and high temporal SNR compared with both single-echo and dual-echo EPI. Patient perfusion data showed that the spiral acquisition achieved accurate DSC quantification comparable to SOC single-echo dual-dose EPI, with the additional DCE information. CONCLUSION: A 3D dual-echo spiral technique was developed to simultaneously acquire both DSC and DCE data in a single-bolus injection with reduced contrast use. Preliminary volunteer and patient data demonstrated increased temporal SNR, reduced geometric artifacts, and accurate perfusion quantification, suggesting a competitive alternative to SOC-EPI techniques for brain perfusion MRI.","journal":"Magnetic Resonance in Medicine","year":2024,"id":476459,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9544,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1313998,"name":"Dinghui Wang","orcid":"0000-0002-7403-3759","position":1,"is_corresponding":false},{"id":1313999,"name":"Melvyn B. Ooi","orcid":"0000-0003-2221-4926","position":2,"is_corresponding":false},{"id":1314420,"name":"Poonam Choudhary","orcid":null,"position":3,"is_corresponding":false},{"id":760900,"name":"Sudarshan Ragunathan","orcid":"0000-0002-2871-1758","position":4,"is_corresponding":false},{"id":760903,"name":"John P. Karis","orcid":"0000-0003-4181-4185","position":5,"is_corresponding":false},{"id":729548,"name":"James G. Pipe","orcid":"0000-0002-7858-1162","position":6,"is_corresponding":false},{"id":247455,"name":"C. Chad Quarles","orcid":"0000-0002-1731-0940","position":7,"is_corresponding":false},{"id":477665,"name":"Ashley M. Stokes","orcid":"0000-0003-1137-5003","position":8,"is_corresponding":false},{"id":1313997,"name":"Zhiqiang Li","orcid":"0000-0003-1085-5734","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T02:06:29.605760Z","pmid":"38469930","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}