{"doi":"10.1002/mrm.29944","title":"Validation of single reference variable flip angle (<scp>SR‐VFA</scp>) dynamic <scp>T<sub>1</sub></scp> mapping with <scp><i>T</i><sub>2</sub></scp>* correction using a novel rotating phantom","abstract":"Abstract Purpose To validate single reference variable flip angle (SR‐VFA) dynamic T 1 mapping with and without T 2 * correction against inversion recovery (IR) T 1 measurements. Methods A custom cylindrical phantom with three concentric compartments was filled with variably doped agar to produce a smooth spatial gradient of the T 1 relaxation rate as a function of angle across each compartment. IR T 1 , VFA T 1 , and B 1 + measurements were made on the phantom before rotation, and multi‐echo stack‐of‐radial dynamic images were acquired during rotation via an MRI‐compatible motor. B 1 + ‐corrected SR‐VFA and SR‐VFA‐ T 2 * T 1 maps were computed from the sliding window reconstructed images and compared against rotationally registered IR and VFA T 1 maps to determine the percentage error. Results Both VFA and SR‐VFA‐ T 2 * T 1 maps fell within 10% of IR T 1 measurements for a low rotational speed, with a mean accuracy of 2.3% ± 2.6% and 2.8% ± 2.6%, respectively. Increasing rotational speed was found to decrease the accuracy due to increasing temporal smoothing over ranges where the T 1 change had a nonconstant slope. SR‐VFA T 1 mapping was found to have similar accuracy as the SR‐VFA‐ T 2 * and VFA methods at low TEs (˜&lt;2 ms), whereas accuracy degraded strongly with later TEs. T 2 * correction of the SR‐VFA T 1 maps was found to consistently improve accuracy and precision, especially at later TEs. Conclusion SR‐VFA‐ T 2 * dynamic T 1 mapping was found to be accurate against reference IR T 1 measurements within 10% in an agar phantom. Further validation is needed in mixed fat–water phantoms and in vivo.","journal":"Magnetic Resonance in Medicine","year":2023,"id":356810,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9591,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":388327,"name":"Henrik Odéen","orcid":"0000-0003-2055-9795","position":1,"is_corresponding":false},{"id":388326,"name":"Lorne W. Hofstetter","orcid":"0000-0003-0041-6711","position":2,"is_corresponding":false},{"id":391212,"name":"J. Rock Hadley","orcid":"0000-0003-1021-4718","position":3,"is_corresponding":false},{"id":388330,"name":"Dennis L. Parker","orcid":"0000-0003-2557-8952","position":4,"is_corresponding":false},{"id":930573,"name":"Michael A. Malmberg","orcid":"0000-0003-0897-4494","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T01:13:30.556819Z","pmid":"38115639","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}