{"doi":"10.1002/mrm.29716","title":"Dynamic lung water MRI during exercise stress","abstract":"PURPOSE: Exercise-induced dyspnea caused by lung water is an early heart failure symptom. Dynamic lung water quantification during exercise is therefore of interest to detect early stage disease. This study developed a time-resolved 3D MRI method to quantify transient lung water dynamics during rest and exercise stress. METHODS: The method was evaluated in 15 healthy subjects and 2 patients with heart failure imaged in transitions between rest and exercise, and in a porcine model of dynamic extravascular lung water accumulation through mitral regurgitation (n = 5). Time-resolved images were acquired at 0.55T using a continuous 3D stack-of-spirals proton density weighted sequence with 3.5 mm isotropic resolution, and derived using a motion corrected sliding-window reconstruction with 90-s temporal resolution in 20-s increments. A supine MRI-compatible pedal ergometer was used for exercise. Global and regional lung water density (LWD) and percent change in LWD (ΔLWD) were automatically quantified. RESULTS: A ΔLWD increase of 3.3 ± 1.5% was achieved in the animals. Healthy subjects developed a ΔLWD of 7.8 ± 5.0% during moderate exercise, peaked at 16 ± 6.8% during vigorous exercise, and remained unchanged over 10 min at rest (-1.4 ± 3.5%, p = 0.18). Regional LWD were higher posteriorly compared the anterior lungs (rest: 33 ± 3.7% vs 20 ± 3.1%, p < 0.0001; peak exercise: 36 ± 5.5% vs 25 ± 4.6%, p < 0.0001). Accumulation rates were slower in patients than healthy subjects (2.0 ± 0.1%/min vs 2.6 ± 0.9%/min, respectively), whereas LWD were similar at rest (28 ± 10% and 28 ± 2.9%) and peak exercise (ΔLWD 17 ± 10% vs 16 ± 6.8%). CONCLUSION: Lung water dynamics can be quantified during exercise using continuous 3D MRI and a sliding-window image reconstruction.","journal":"Magnetic Resonance in Medicine","year":2023,"id":346218,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.953,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":512515,"name":"Ahsan Javed","orcid":"0000-0003-1311-1247","position":1,"is_corresponding":false},{"id":294239,"name":"Jaffar M. Khan","orcid":"0000-0001-6099-0753","position":2,"is_corresponding":false},{"id":294244,"name":"Christopher G. Bruce","orcid":"0000-0002-7442-4303","position":3,"is_corresponding":false},{"id":782444,"name":"Rachel Chae","orcid":"0000-0003-3655-8164","position":4,"is_corresponding":false},{"id":294243,"name":"Dursun Korel Yildirim","orcid":"0000-0002-1145-939X","position":5,"is_corresponding":false},{"id":1086578,"name":"Amanda Potersnak","orcid":"0009-0006-2603-7946","position":6,"is_corresponding":false},{"id":1086579,"name":"Haiyan Wang","orcid":"0000-0002-5204-967X","position":7,"is_corresponding":false},{"id":1087100,"name":"Scott Baute","orcid":null,"position":8,"is_corresponding":false},{"id":329135,"name":"Rajiv Ramasawmy","orcid":"0000-0002-9821-9187","position":9,"is_corresponding":false},{"id":294247,"name":"Robert J. Lederman","orcid":"0000-0003-1202-6673","position":10,"is_corresponding":false},{"id":280607,"name":"Adrienne Campbell‐Washburn","orcid":"0000-0002-7169-5693","position":11,"is_corresponding":false},{"id":865981,"name":"Felicia Seemann","orcid":"0000-0003-3074-5380","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T01:11:48.317335Z","pmid":"37288601","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}