{"doi":"10.1002/mrm.28936","title":"In vivo<sup>1</sup>H MR spectroscopy with<i>J</i>‐refocusing","abstract":"Purpose The goal of this study was to propose a novel localized proton MR spectroscopy (MRS) sequence that reduces signal loss due to J ‐modulation in the rat brain in vivo. Methods Sprague‐Dawley rats were studied at 9.4 T. A semi‐LASER sequence with evenly distributed echo‐time (T E ) was used, and a 90° J ‐refocusing pulse was inserted at T E /2. Proton spectra were acquired at two T E s (30 and 68 ms), with and without the J ‐refocused pulse. Data were processed in MATLAB and quantified with LCModel. Results The J ‐refocused spectrum acquired at T E = 30 ms did not show any signal losses due to J ‐modulation and had comparable spectral pattern to the one acquired with semi‐LASER using the minimum achievable T E . Higher signal amplitudes for glutamine, γ‐aminobutyric acid and glutathione led to more reliable quantification precision for these metabolites. The refocused signal intensities at T E = 68 ms were also unaffected by J ‐modulation but were smaller than the signals at T E = 30 ms mainly due to transverse T 2 relaxation of metabolites. Conclusion The proposed localized MRS sequence will be beneficial in both animal and human MRS studies when using ultra‐short T E is not possible while also providing more reliable quantification precision for J ‐coupled metabolites.","journal":"Magnetic Resonance in Medicine","year":2021,"id":207651,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9644,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":793244,"name":"Jamie D. Walls","orcid":"0000-0003-4813-852X","position":1,"is_corresponding":false},{"id":489090,"name":"Małgorzata Marjańska","orcid":"0000-0002-4727-2447","position":2,"is_corresponding":false},{"id":494347,"name":"Dinesh K. Deelchand","orcid":"0000-0003-4266-4780","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-18T23:51:49.715594Z","pmid":"34309065","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}