{"doi":"10.1002/mrm.28283","title":"Three‐dimensional motion‐corrected T<sub>1</sub> relaxometry with MPnRAGE","abstract":"Purpose To test the performance of the MPnRAGE motion‐correction algorithm on quantitative relaxometry estimates. Methods Twelve children (9.4 ± 2.6 years, min = 6.5 years, max = 13.8 years) were imaged 3 times in a session without sedation. Stabilization padding was not used for the second and third scans. Quantitative T 1 values were estimated in each voxel on images reconstructed with and without motion correction. Mean T 1 values were assessed in various regions determined from automated segmentation algorithms. Statistical tests were performed on mean values and the coefficient of variation across the measurements. Accuracy of T 1 estimates were determined by scanning the High Precision Devices (Boulder, CO) MRI system phantom with the same protocol. Results The T 1 values obtained with MPnRAGE agreed within 4% of the reference values of the High Precision Devices phantom. The best fit line was T 1 (MPnRAGE) = 1.02 T 1 (reference)—0.9 ms, R 2 = 0.9999. For in vivo studies, motion correction reduced the coefficients of variation of mean T 1 values in whole‐brain tissue regions determined by FSL FAST by 74% ± 7%, and subcortical regions determined by FIRST and FreeSurfer by 32% ± 21% and 33% ± 26%, respectively. Across all participants, the mean coefficients of variation ranged from 0.8% to 2.0% for subcortical regions and 0.6% ± 0.5% for cortical regions when motion correction was applied. Conclusion The MPnRAGE technique demonstrated highly accurate values in phantom measurements. When combined with retrospective motion correction, MPnRAGE demonstrated highly reproducible T 1 values, even in participants who moved during the acquisition.","journal":"Magnetic Resonance in Medicine","year":2020,"id":75955,"datarank":0.47032413238937254,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.0,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9087,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":396751,"name":"Andrew L. Alexander","orcid":"0000-0003-2695-768X","position":1,"is_corresponding":false},{"id":396750,"name":"Steven Kecskemeti","orcid":"0000-0003-3589-430X","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:47:46.469293Z","pmid":"32301173","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}