{"doi":"10.1002/mrm.28250","title":"Impact of age, sex, and global function on normal aortic hemodynamics","abstract":"PURPOSE: To examine the effects of age, sex, and left ventricular global function on velocity, helicity, and 3D wall shear stress (3D-WSS) in the aorta of N = 100 healthy controls. METHODS: Fifty female and 50 male volunteers with no history of cardiovascular disease, with 10 volunteers per age group (18-30, 31-40, 41-50, 51-60, and 61-80 years) underwent aortic 4D-flow MRI. Quantification of systolic aortic peak velocity, helicity, and 3D-WSS distribution and the calculation of age group-averaged peak systolic velocity and 3D-WSS maps (\"atlases\") were computed. Age-related and sex-related changes in peak velocity, helicity, and 3D-WSS were computed and correlated with standard metrics of left ventricular function derived from short-axis cine MRI. RESULTS: No significant differences were found in peak systolic velocity or 3D-WSS based on sex except for the 18- to 30-year-old group (males 8% higher velocity volume and 3D-WSS surface area). Between successively older groups, systolic velocity decreased (13%, <1%, 7%, and 55% of the aorta volume) and 3D-WSS decreased (21%, 2%, 30%, and 62% of the aorta surface area). Mean velocity, mean 3D-3D-WSS, and median helicity increased with cardiac output (r = 0.27-0.43, all P < .01), and mean velocity and 3D-WSS decreased with increasing diameter (r > 0.35, P < .001). Arch and descending aorta systolic mean velocity, mean 3D-WSS, and median helicity increased with normalized left ventricular volumes: end diastolic volume (r = 0.31-0.37, P < .01), end systolic volume (r = 0.27-0.35, P < .01), and stroke volume (r = 0.28-0.35, P < .01). CONCLUSION: Healthy aortic hemodynamics are dependent on subject age, and correlate with vessel diameter and cardiac function.","journal":"Magnetic Resonance in Medicine","year":2020,"id":100556,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7556,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":494656,"name":"Hyungkyu Huh","orcid":null,"position":1,"is_corresponding":false},{"id":493626,"name":"Pim van Ooij","orcid":"0000-0001-8755-0192","position":2,"is_corresponding":false},{"id":493627,"name":"Vincent Chen","orcid":"0000-0001-6757-6432","position":3,"is_corresponding":false},{"id":493628,"name":"Brenda Herrera","orcid":"0009-0008-7650-9459","position":4,"is_corresponding":false},{"id":493629,"name":"Mohammed S.M. Elbaz","orcid":"0000-0001-5051-5668","position":5,"is_corresponding":false},{"id":493630,"name":"Patrick M. McCarthy","orcid":"0000-0001-6729-2405","position":6,"is_corresponding":false},{"id":494657,"name":"S. Chris Malaisrie","orcid":null,"position":7,"is_corresponding":false},{"id":319742,"name":"James Carr","orcid":"0000-0003-1380-8095","position":8,"is_corresponding":false},{"id":387464,"name":"Paul W.M. Fedak","orcid":"0000-0003-0658-9381","position":9,"is_corresponding":false},{"id":319743,"name":"Michael Markl","orcid":"0000-0002-7686-1128","position":10,"is_corresponding":false},{"id":493631,"name":"Alex J. Barker","orcid":"0000-0002-6283-9157","position":11,"is_corresponding":false},{"id":470917,"name":"Michael Scott","orcid":"0000-0001-7160-4248","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-18T22:39:01.863288Z","pmid":"32162416","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}