{"doi":"10.1002/mrm.28207","title":"Measuring diffusion exchange across the cell membrane with DEXSY (Diffusion Exchange Spectroscopy)","abstract":"INTRODUCTION: To combine numerical simulations, in vitro and in vivo experiments to evaluate the feasibility of measuring diffusion exchange across the cell membrane with diffusion exchange spectroscopy (DEXSY). METHODS: DEXSY acquisitions were simulated over a range of permeabilities in nerve tissue and yeast substrates. In vitro measurements were performed in a yeast substrate and in vivo measurements in mouse tumor xenograft models, all at 9.4 T. RESULTS: Diffusion exchange was observed in simulations over a physiologically relevant range of cell permeability values. In vitro and in vivo measures also provided evidence of diffusion exchange, which was quantified with the Diffusion Exchange Index (DEI). CONCLUSIONS: Our findings provide preliminary evidence that DEXSY can be used to make in vivo measurements of diffusion exchange and cell membrane permeability.","journal":"Magnetic Resonance in Medicine","year":2020,"id":78489,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7411,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":408614,"name":"Bernard Siow","orcid":"0000-0002-8687-8783","position":1,"is_corresponding":false},{"id":408615,"name":"Claire Walsh","orcid":"0000-0003-3769-3392","position":2,"is_corresponding":false},{"id":410240,"name":"Ben Hipwell","orcid":null,"position":3,"is_corresponding":false},{"id":410241,"name":"Ioana Hill","orcid":null,"position":4,"is_corresponding":false},{"id":408616,"name":"Thomas A. Roberts","orcid":"0000-0003-0385-1057","position":5,"is_corresponding":false},{"id":408617,"name":"Matt G. Hall","orcid":"0000-0002-9530-5477","position":6,"is_corresponding":false},{"id":277644,"name":"Mark F. Lythgoe","orcid":"0000-0002-4945-0171","position":7,"is_corresponding":false},{"id":408618,"name":"Andrada Ianuș","orcid":"0000-0001-9893-1724","position":8,"is_corresponding":false},{"id":244799,"name":"Daniel C. Alexander","orcid":"0000-0003-2439-350X","position":9,"is_corresponding":false},{"id":408619,"name":"Simon Walker‐Samuel","orcid":"0000-0003-3530-9166","position":10,"is_corresponding":false},{"id":408613,"name":"James O. Breen‐Norris","orcid":"0000-0002-0668-7136","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-18T21:50:09.793321Z","pmid":"32060975","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}