{"doi":"10.1002/mrd.23316","title":"Mouse strain‐dependent egg factors regulate calcium signals at fertilization","abstract":"Abstract Calcium (Ca 2+ ) signals triggered at fertilization initiate resumption of the cell cycle and initial steps of embryonic development. In mammals, the sperm factor phospholipase Cζ triggers the release of Ca 2+ from the endoplasmic reticulum (ER), initiating an oscillatory pattern of Ca 2+ transients that is modulated by egg factors including Ca 2+ influx channels, Ca 2+ transporters, and phosphoinositide‐regulating enzymes. Here we compared characteristics of Ca 2+ oscillations following in vitro fertilization (IVF) and ER Ca 2+ stores among nine common laboratory mouse strains: CF1, C57BL6, SJL, CD1, DBA, FVB, 129X1, BALBc, 129S1, and the F1 hybrid B6129SF1. Sperm from B6SJLF1/J males was used for all IVF experiments. There were significant differences among the strains with respect to duration and maximum amplitude of the first Ca 2+ transient, frequency of oscillations, and ER Ca 2+ stores. With male strain held constant, the differences in Ca 2+ oscillation patterns observed result from variation in egg factors across different mouse strains. Our results support the importance of egg‐intrinsic properties in determining Ca 2+ oscillation patterns and have important implications for the interpretation and comparison of studies on Ca 2+ dynamics at fertilization.","journal":"Molecular Reproduction and Development","year":2020,"id":115490,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9472,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":541074,"name":"Miranda L. Bernhardt","orcid":"0000-0001-5424-5685","position":1,"is_corresponding":false},{"id":310698,"name":"Carmen J. Williams","orcid":"0000-0001-6440-7086","position":2,"is_corresponding":false},{"id":541073,"name":"Caitlin E. McDonough-Goldstein","orcid":"0000-0001-8949-7479","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-18T23:13:36.820928Z","pmid":"31944466","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}