{"doi":"10.1002/mpr.1984","title":"An exploration of actigraphy in the context of ketamine and treatment‐resistant depression","abstract":"OBJECTIVES: This study explored the potential of non-parametric and complexity analysis metrics to detect changes in activity post-ketamine and their association with depressive symptomatology. METHODS: Individuals with treatment-resistant depression (TRD: n = 27, 16F, 35.9 ± 10.8 years) and healthy volunteers (HVs: n = 9, 4F, 36.4 ± 9.59 years) had their activity monitored during an inpatient, double-blind, crossover study where they received an infusion of ketamine or saline placebo. All participants were 18-65 years old, medication-free, and had a MADRS score ≥20. Non-parametric metrics averaged over each study day, metrics derived from complexity analysis, and traditionally calculated non-parametric metrics averaged over two weeks were calculated from the actigraphy time series. A separate analysis was conducted for a subsample (n = 17) to assess the utility of these metrics in a hospital setting. RESULTS: In HVs, lower intradaily variability was observed within daily rest/activity patterns post-ketamine versus post-placebo (F = 5.16(1,15), p = 0.04). No other significant effects of drug or drug-by-time or correlations between depressive symptomatology and activity were detected. CONCLUSIONS: Weak associations between non-parametric variables and ketamine were found but were not consistent across actigraphy measures. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT00088699.","journal":"International Journal of Methods in Psychiatric Research","year":2023,"id":377521,"datarank":0.21414599736246734,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.00620184319448372,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.00620184319448372,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":2,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9231,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT00088699"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":796567,"name":"Wallace C. Duncan","orcid":null,"position":1,"is_corresponding":false},{"id":362557,"name":"Dede Greenstein","orcid":null,"position":2,"is_corresponding":false},{"id":642429,"name":"Gavi Shandler","orcid":"0000-0001-9470-3943","position":3,"is_corresponding":false},{"id":230008,"name":"Carlos A. Zarate","orcid":"0000-0003-4442-7412","position":4,"is_corresponding":false},{"id":240739,"name":"Jennifer W. Evans","orcid":"0009-0002-7176-5759","position":5,"is_corresponding":false},{"id":1070927,"name":"Claire Punturieri","orcid":"0009-0003-7743-3736","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T01:16:40.346877Z","pmid":"37668277","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}