{"doi":"10.1002/mnfr.202300286","title":"Sulforaphane and Sulforaphane‐Nitrile Metabolism in Humans Following Broccoli Sprout Consumption: Inter‐individual Variation, Association with Gut Microbiome Composition, and Differential Bioactivity","abstract":"SCOPE: The glucosinolate glucoraphanin from broccoli is converted to sulforaphane (SFN) or sulforaphane-nitrile (SFN-NIT) by plant enzymes or the gut microbiome. Human feeding studies typically observe high inter-individual variation in absorption and excretion of SFN, however, the source of this variation is not fully known. To address this, a human feeding trial to comprehensively evaluate inter-individual variation in the absorption and excretion of all known SFN metabolites in urine, plasma, and stool, and tested the hypothesis that gut microbiome composition influences inter-individual variation in total SFN excretion has been conducted. METHODS AND RESULTS: Participants (n = 55) consumed a single serving of broccoli or alfalfa sprouts and plasma, stool, and total urine are collected over 72 h for quantification of SFN metabolites and gut microbiome profiling using 16S gene sequencing. SFN-NIT excretion is markedly slower than SFN excretion (72 h vs 24 h). Members of genus Bifidobacterium, Dorea, and Ruminococcus torques are positively associated with SFN metabolite excretion while members of genus Alistipes and Blautia has a negative association. CONCLUSION: This is the first report of SFN-NIT metabolite levels in human plasma, urine, and stool following consumption of broccoli sprouts. The results help explain factors driving inter-individual variation in SFN metabolism and are relevant for precision nutrition.","journal":"Molecular Nutrition & Food Research","year":2023,"id":329118,"datarank":0.6351549446264119,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.17149857662266435,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.17149857662266435,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":17,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9498,"is_data_producer":true,"deposit_databanks":{"SRA":["PRJNA953404"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":475153,"name":"Laura M. Beaver","orcid":"0000-0002-0352-573X","position":1,"is_corresponding":false},{"id":411967,"name":"Carmen P. Wong","orcid":"0000-0001-8294-2584","position":2,"is_corresponding":false},{"id":392650,"name":"Jaewoo Choi","orcid":"0000-0001-6376-3089","position":3,"is_corresponding":false},{"id":1052357,"name":"Sean Hamer","orcid":null,"position":4,"is_corresponding":false},{"id":890433,"name":"Edward W. Davis","orcid":"0000-0003-1229-4272","position":5,"is_corresponding":false},{"id":560759,"name":"Kevin Brown","orcid":"0000-0003-2959-2401","position":6,"is_corresponding":false},{"id":54825,"name":"Duo Jiang","orcid":"0000-0002-7103-4502","position":7,"is_corresponding":false},{"id":29164,"name":"Thomas J. Sharpton","orcid":"0000-0002-5996-7764","position":8,"is_corresponding":false},{"id":258941,"name":"Jan F. Stevens","orcid":"0000-0002-6348-9347","position":9,"is_corresponding":false},{"id":535043,"name":"Emily Ho","orcid":"0000-0002-7687-2820","position":10,"is_corresponding":false},{"id":675429,"name":"John A. Bouranis","orcid":"0000-0002-5533-7570","position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":null,"created_at":"2026-07-19T01:09:01.509601Z","pmid":"38143283","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}