{"doi":"10.1002/mnfr.202100549","title":"Allulose Attenuated Age‐Associated Sarcopenia via Regulating IGF‐1 and Myostatin in Aged Mice","abstract":"<jats:sec><jats:title>Scope</jats:title><jats:p>Allulose is shown to increase the muscle weight in diet‐induced obese mice. However, there are no studies on the effects of allulose in age‐associated sarcopenia. This study aims to elucidate the mechanisms of action for allulose in age associated by analyzing the transcriptional patterns in aged mice.</jats:p></jats:sec><jats:sec><jats:title>Methods and Results</jats:title><jats:p>The 48‐week‐old mice are fed with AIN‐93diet containing allulose for 12 weeks. Allulose supplementation increases the muscle mass and grip strength in aged mice. Allulose increases the insulin‐like growth factor 1 (IGF‐1) and its downstream factor expressions which 40 are related protein synthesis, while inhibits the myostatin expression related protein degradation. In mRNA‐seq analysis, allulose supplementation significantly decreases in Adiponectin, Adipsin, cell death inducing DFFA like effector (CIDEC), Haptoglobin, Neuroglobin, and stearoyl‐CoA desaturase‐1 (SCD1) and increases in cytokine‐inducible SH2‐containing protein (CISH) and ceramide synthase 1 (CerS1) that are regulate protein turn over in gastrocnemius. Also, allulose alleviates autophagy in muscle with regulated mammalian target of rapamycin (mTOR) signaling pathway and increases the anti‐oxidant enzyme activity.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>These findings suggest that allulose improves the age‐associated sarcopenia with enhancing antioxidant properties by altering mRNA and protein expression.</jats:p></jats:sec>","journal":"Molecular Nutrition &amp; Food Research","year":2022,"id":635482,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1648727,"name":"Eun‐Young Kwon","orcid":null,"position":1,"is_corresponding":false},{"id":1648729,"name":"Youngji Han","orcid":"0000-0003-2270-8176","position":2,"is_corresponding":false},{"id":288690,"name":"Ji‐Eun Kim","orcid":"0000-0003-4709-262X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Allulose Attenuated Age‐Associated Sarcopenia via Regulating IGF‐1 and Myostatin in Aged Mice","abstract":"<jats:sec><jats:title>Scope</jats:title><jats:p>Allulose is shown to increase the muscle weight in diet‐induced obese mice. However, there are no studies on the effects of allulose in age‐associated sarcopenia. This study aims to elucidate the mechanisms of action for allulose in age associated by analyzing the transcriptional patterns in aged mice.</jats:p></jats:sec><jats:sec><jats:title>Methods and Results</jats:title><jats:p>The 48‐week‐old mice are fed with AIN‐93diet containing allulose for 12 weeks. Allulose supplementation increases the muscle mass and grip strength in aged mice. Allulose increases the insulin‐like growth factor 1 (IGF‐1) and its downstream factor expressions which 40 are related protein synthesis, while inhibits the myostatin expression related protein degradation. In mRNA‐seq analysis, allulose supplementation significantly decreases in Adiponectin, Adipsin, cell death inducing DFFA like effector (CIDEC), Haptoglobin, Neuroglobin, and stearoyl‐CoA desaturase‐1 (SCD1) and increases in cytokine‐inducible SH2‐containing protein (CISH) and ceramide synthase 1 (CerS1) that are regulate protein turn over in gastrocnemius. Also, allulose alleviates autophagy in muscle with regulated mammalian target of rapamycin (mTOR) signaling pathway and increases the anti‐oxidant enzyme activity.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>These findings suggest that allulose improves the age‐associated sarcopenia with enhancing antioxidant properties by altering mRNA and protein expression.</jats:p></jats:sec>","is_dataset_classified":null,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34710274","pmcid":null,"openalex_id":"https://openalex.org/W3211163267","authors":[],"funders":[{"funder_name":"National Research Foundation of Korea","grant_id":"2020R1I1A1A01067942","title":null},{"funder_name":"National Research Foundation of Korea","grant_id":"2020R1I1A3074694","title":null}],"total_grants":2,"fwci":1.2701,"citation_percentile":0.80949199,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":6},{"year":2024,"count":2},{"year":2025,"count":4}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/mnfr.202100549","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/mnfr.202100549","host_type":"publisher"},{"url":"https://doi.org/10.1002/mnfr.202100549","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34710274","host_type":"repository"}],"fields_of_study":["Diet, Metabolism, and Disease","Lipid metabolism and disorders","Diet and metabolism studies","Animals","Fructose","Insulin-Like Growth Factor I","Mammals","Mice","Mice, Obese","Muscle, Skeletal","Myostatin","Sarcopenia"],"mesh_terms":["Animals","Fructose","Insulin-Like Growth Factor I","Mammals","Mice, Obese","Muscle, Skeletal","Mice","Myostatin","Sarcopenia"],"keywords":["Sarcopenia","Myostatin","Internal medicine","Medicine","Endocrinology","Gerontology","Biology","Skeletal muscle","aged mice","Skeletal Muscle Function","Skeletal Muscle Mass","Allulose","Age-associated Sarcopenia"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T15:10:18.039565Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}