{"doi":"10.1002/mds.30019","title":"Evaluation of Cerebrospinal Fluid <b>α</b>‐Synuclein Seed Amplification Assay in Progressive Supranuclear Palsy and Corticobasal Syndrome","abstract":"BACKGROUND: Seed amplification assay (SAA) testing has been developed as a biomarker for the diagnosis of α-synuclein-related neurodegenerative disorders. OBJECTIVE: The objective of this study was to assess the rate of α-synuclein SAA positivity in progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) and to analyze clinical and pathological features of SAA-positive and -negative cases. METHODS: A total of 96 cerebrospinal fluid samples from clinically diagnosed PSP (n = 59) and CBS (n = 37) cases were analyzed using α-synuclein SAA. RESULTS: Six of 59 (10.2%) PSP cases were α-synuclein SAA positive, including one case who was MSA-type positive. An exploratory analysis showed that PSP cases who were Parkinson's disease-type positive were older and had a shorter disease duration compared with SAA-negative cases. In contrast, 11 of 37 (29.7%) CBS cases were α-synuclein SAA positive, including two cases who were MSA-type positive. CONCLUSIONS: Our results suggest that α-synuclein seeds can be detected in PSP and CBS using a cerebrospinal fluid α-synuclein SAA, and in PSP this may impact on clinical course.","journal":"Movement Disorders","year":2024,"id":422024,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9649,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1215573,"name":"Riona Fumi","orcid":"0009-0007-4917-6559","position":1,"is_corresponding":false},{"id":1215574,"name":"Marte Theilmann Jensen","orcid":"0000-0002-3727-9477","position":2,"is_corresponding":false},{"id":1216278,"name":"Megan Hodgson","orcid":null,"position":3,"is_corresponding":false},{"id":1215575,"name":"Tatiana Georgiades","orcid":"0009-0007-6165-2490","position":4,"is_corresponding":false},{"id":45806,"name":"Lesley Wu","orcid":"0000-0001-5464-5603","position":5,"is_corresponding":false},{"id":1216279,"name":"Danielle Lux","orcid":null,"position":6,"is_corresponding":false},{"id":1216280,"name":"Ruth Obrocki","orcid":null,"position":7,"is_corresponding":false},{"id":483745,"name":"Jennifer Lamoureux","orcid":null,"position":8,"is_corresponding":false},{"id":461713,"name":"Olaf Ansorge","orcid":"0000-0003-1825-5434","position":9,"is_corresponding":false},{"id":271288,"name":"Kieren Allinson","orcid":"0000-0003-3468-2110","position":10,"is_corresponding":false},{"id":271285,"name":"Thomas T. 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