{"doi":"10.1002/mds.29725","title":"Association between Subjective Cognitive Complaints and Incident Functional Impairment in Parkinson's Disease","abstract":"BACKGROUND: Early identification of subjective cognitive complaints (SCC) in Parkinson's disease (PD) may improve patient care if it predicts cognition-related functional impairment (CFI). OBJECTIVES: The aim was to determine the cross-sectional and longitudinal association between SCC and CFI in PD. METHODS: Data were obtained from Fox Insight, an online longitudinal study that collects PD patient-reported outcomes. Participants completed a PD Patient Report of Problems that asked participants for their five most bothersome disease problems. SCCs were placed into eight categories through human-in-the-loop curation and classification. CFI had a Penn Parkinson's Daily Activities Questionnaire (PDAQ-15) score ≤49. Cox proportional hazards models and Kaplan-Meier survival analyses determined if baseline SCC was associated with incident CFI. RESULTS: The PD-PROP cohort (N = 21,160) was 55.8% male, mean age was 65.9 years, and PD duration was 4.8 years. At baseline, 31.9% (N = 6750) of participants reported one or more SCCs among their five most bothersome problems, including memory (13.2%), language/word finding (12.5%), and concentration/attention (9.6%). CFI occurred in 34.7% (N = 7332) of participants. At baseline, SCC was associated with CFI (P-value <0.001). SCC at baseline was associated with incident CFI (hazard ratio [HR] = 1.58 [95% confidence interval: 1.45, 1.72], P-value <0.001), as did cognitive impairment not otherwise specified (HR = 2.31), executive abilities (HR = 1.97), memory (HR = 1.85), and cognitive slowing (HR = 1.77) (P-values <0.001). Kaplan-Meier curves showed that by year 3 an estimated 45% of participants with any SCC at baseline developed new-onset CFI. CONCLUSIONS: Self-reported bothersome cognitive complaints are associated with new-onset CFI in PD. Remote electronic assessment can facilitate widespread use of patient self-report at population scale. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.","journal":"Movement Disorders","year":2024,"id":434774,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8009,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":341997,"name":"Connie Marras","orcid":"0000-0002-9236-9328","position":1,"is_corresponding":false},{"id":230244,"name":"Amy W. Amara","orcid":"0000-0003-0762-9656","position":2,"is_corresponding":false},{"id":918847,"name":"Karen E. Anderson","orcid":"0000-0002-2084-6869","position":3,"is_corresponding":false},{"id":246440,"name":"Lana M. Chahine","orcid":"0000-0003-2521-7196","position":4,"is_corresponding":false},{"id":80295,"name":"Shirley Eberly","orcid":"0009-0005-2338-2499","position":5,"is_corresponding":false},{"id":1194961,"name":"Abhishek Hosamath","orcid":"0000-0002-8243-0682","position":6,"is_corresponding":false},{"id":317508,"name":"Daniel Kinel","orcid":"0000-0002-3082-230X","position":7,"is_corresponding":false},{"id":692319,"name":"Sneha Mantri","orcid":"0000-0003-4556-0522","position":8,"is_corresponding":false},{"id":1174160,"name":"Soania Mathur","orcid":"0000-0002-6224-7573","position":9,"is_corresponding":false},{"id":341995,"name":"David Oakes","orcid":"0000-0002-9154-6054","position":10,"is_corresponding":false},{"id":1021451,"name":"Jennifer L. Purks","orcid":"0000-0003-4334-8253","position":11,"is_corresponding":false},{"id":230245,"name":"David G. Standaert","orcid":"0000-0003-2921-8348","position":12,"is_corresponding":false},{"id":317516,"name":"Ira Shoulson","orcid":"0000-0001-6140-1797","position":13,"is_corresponding":false},{"id":1194960,"name":"Lakshmi Arbatti","orcid":"0000-0002-9219-1961","position":14,"is_corresponding":false},{"id":80309,"name":"Daniel Weintraub","orcid":"0000-0003-0633-7168","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T01:59:58.582186Z","pmid":"38318953","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}