{"doi":"10.1002/mds.29634","title":"Paradoxical Modulation of <scp>STN β‐Band</scp> Activity with Medication Compared to Deep Brain Stimulation","abstract":"BACKGROUND: Excessive subthalamic nucleus (STN) β-band (13-35 Hz) synchronized oscillations has garnered interest as a biomarker for characterizing disease state and developing adaptive stimulation systems for Parkinson's disease (PD). OBJECTIVES: To report on a patient with abnormal treatment-responsive modulation in the β-band. METHODS: We examined STN local field potentials from an externalized deep brain stimulation (DBS) lead while assessing PD motor signs in four conditions (OFF, MEDS, DBS, and MEDS+DBS). RESULTS: The patient presented here exhibited a paradoxical increase in β power following administration of levodopa and pramipexole (MEDS), but an attenuation in β power during DBS and MEDS+DBS despite clinical improvement of 50% or greater under all three therapeutic conditions. CONCLUSIONS: This case highlights the need for further study on the role of β oscillations in the pathophysiology of PD and the importance of personalized approaches to the development of β or other biomarker-based DBS closed loop algorithms. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.","journal":"Movement Disorders","year":2023,"id":366292,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.949,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":240696,"name":"Luke A. Johnson","orcid":"0000-0002-9069-1436","position":1,"is_corresponding":false},{"id":473211,"name":"Jing Wang","orcid":"0000-0002-9883-4972","position":2,"is_corresponding":false},{"id":569721,"name":"David Escobar Sanabria","orcid":"0000-0001-6402-806X","position":3,"is_corresponding":false},{"id":392540,"name":"Rémi Patriat","orcid":"0000-0003-2928-3772","position":4,"is_corresponding":false},{"id":451806,"name":"Scott E. Cooper","orcid":"0000-0003-4263-9593","position":5,"is_corresponding":false},{"id":473215,"name":"Michael C. Park","orcid":"0000-0002-5680-0811","position":6,"is_corresponding":false},{"id":320268,"name":"Noam Harel","orcid":"0000-0002-6034-3801","position":7,"is_corresponding":false},{"id":240700,"name":"Jerrold L. Vitek","orcid":"0000-0002-2308-6535","position":8,"is_corresponding":false},{"id":473210,"name":"Joshua E. Aman","orcid":"0000-0003-1242-062X","position":9,"is_corresponding":false},{"id":473212,"name":"Meghan Hill","orcid":"0000-0001-9019-1186","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T01:14:55.198227Z","pmid":"37888906","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}