{"doi":"10.1002/mds.29347","title":"Pallidal Beta Activity Is Linked to Stimulation‐Induced Slowness in Dystonia","abstract":"BACKGROUND: Pallidal deep brain stimulation (DBS) effectively alleviates symptoms in dystonia patients, but may induce movement slowness as a side-effect. In Parkinson's disease, hypokinetic symptoms have been associated with increased beta oscillations (13-30 Hz). We hypothesize that this pattern is symptom-specific, thus accompanying DBS-induced slowness in dystonia. METHODS: In 6 dystonia patients, pallidal rest recordings with a sensing-enabled DBS device were performed and tapping speed was assessed using marker-less pose estimation over 5 time points following cessation of DBS. RESULTS: After cessation of pallidal stimulation, movement speed increased over time (P < 0.01). A linear mixed-effects model revealed that pallidal beta activity explained 77% of the variance in movement speed across patients (P = 0.01). CONCLUSIONS: The association between beta oscillations and slowness across disease entities provides further evidence for symptom-specific oscillatory patterns in the motor circuit. Our findings might help DBS therapy improvements, as DBS-devices able to adapt to beta oscillations are already commercially available. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.","journal":"Movement Disorders","year":2023,"id":330951,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9542,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":905945,"name":"Ute Scheller","orcid":"0000-0003-4202-2470","position":1,"is_corresponding":false},{"id":1055751,"name":"Aurika Mindermann","orcid":null,"position":2,"is_corresponding":false},{"id":1055301,"name":"Lucia K. Feldmann","orcid":"0000-0003-1290-208X","position":3,"is_corresponding":false},{"id":852471,"name":"Andreas Horn","orcid":"0000-0002-0675-9064","position":4,"is_corresponding":false},{"id":1055302,"name":"Assel Saryyeva","orcid":"0000-0001-7270-3010","position":5,"is_corresponding":false},{"id":863255,"name":"Gerd‐Helge Schneider","orcid":"0000-0002-1301-2938","position":6,"is_corresponding":false},{"id":232910,"name":"Andrea A. Kühn","orcid":"0000-0002-4134-9060","position":7,"is_corresponding":false},{"id":905943,"name":"Roxanne Lofredi","orcid":"0000-0002-1845-8250","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T01:09:14.691473Z","pmid":"36807626","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}