{"doi":"10.1002/mds.29343","title":"<scp>LRRK2</scp>‐Targeting Therapies March Through the Valley of Death","abstract":"In this issue, Jennings et al describe the emergence of the leucine-rich repeat kinase 2 (LRRK2) inhibitor BIIB122 from the valley of death. 1 The valley of death is the formidable abyss that exists between target identification and first-in-human studies. 2 It is so named because few targets and therapeutics that enter the valley make it out the other side; Jennings et al present a rare look into the valley of death not typically published in Parkinson's disease (PD) neuroprotectants.The study involved 186 healthy participants as well as 36 PD patients, randomly assigned and treated in phase 1 and 1b studies, respectively.Endpoints that were disclosed related to BIIB122 pharmacodynamics, target (ie, LRRK2) engagement in different biomarker assays, and safety in 28-day dosing.BIIB122 follows a previous publication on the LRRK2 kinase inhibitor DNL201.","journal":"Movement Disorders","year":2023,"id":360386,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9428,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":263854,"name":"Michael A. Schwarzschild","orcid":"0000-0001-6019-8280","position":1,"is_corresponding":false},{"id":307808,"name":"Andrew B. West","orcid":"0000-0002-3034-4061","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T01:14:01.896928Z","pmid":"36942368","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}