{"doi":"10.1002/mds.28761","title":"Polygenic Risk Scores in a Prospective Parkinson's Disease Cohort","abstract":"BACKGROUND: Ethnic-specific genetic risk assessment framework for Parkinson's disease (PD) is lacking for the Asian population. OBJECTIVE: We investigated the association of a polygenic risk score (PRS) with PD incidence in a population-based Asian prospective cohort. METHODS: Genetic, dietary, and lifestyle information were prospectively collected from 25,646 participants within the Singapore Chinese Health Study cohort. PRS was constructed with Asian-specific and top genome-wide association study variants. The association between PRS and PD incidence was evaluated with multivariable Cox proportional hazard models, Kaplan-Meier survival analysis, and concordance statistics. RESULTS: A total of 333 incident cases were identified after a follow-up period of more than 20 years. Participants with PRS in the top tertile (hazard ratio [HR], 1.81; 95% confidence interval [CI], 1.37-2.39) and middle tertile (HR, 1.35; 95% CI, 1.00-1.83) are at higher risk of developing PD after adjusting for dietary and lifestyle risk factors, with a shorter time to PD event in a Kaplan-Meier survival analysis (P < 0.001). CONCLUSION: We identified a PRS that was significantly associated with PD incidence in a prospective Chinese cohort after adjusting for dietary and lifestyle factors. © 2021 International Parkinson and Movement Disorder Society.","journal":"Movement Disorders","year":2021,"id":200397,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6791,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":270071,"name":"Jia Nee Foo","orcid":"0000-0001-9899-2308","position":1,"is_corresponding":false},{"id":461905,"name":"Seyed Ehsan Saffari","orcid":"0000-0002-6473-4375","position":2,"is_corresponding":false},{"id":778737,"name":"Aidan Sheng‐Yong Wong","orcid":null,"position":3,"is_corresponding":false},{"id":90169,"name":"Chiea Chuen Khor","orcid":"0000-0002-1128-4729","position":4,"is_corresponding":false},{"id":341681,"name":"Jian‐Min Yuan","orcid":"0000-0002-4620-3108","position":5,"is_corresponding":false},{"id":488759,"name":"Eng‐King Tan","orcid":"0000-0003-2977-9743","position":6,"is_corresponding":false},{"id":260003,"name":"Woon‐Puay Koh","orcid":"0000-0002-5674-6341","position":7,"is_corresponding":false},{"id":778738,"name":"Louis C.S. Tan","orcid":null,"position":8,"is_corresponding":false},{"id":778080,"name":"Ming Wei Sia","orcid":"0000-0002-8765-7755","position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":null,"created_at":"2026-07-18T23:50:48.624274Z","pmid":"34402545","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}