{"doi":"10.1002/mds.28640","title":"Lack of Causal Effects or Genetic Correlation between Restless Legs Syndrome and Parkinson's Disease","abstract":"BACKGROUND: Epidemiological studies have reported an association between Parkinson's disease (PD) and restless legs syndrome. OBJECTIVES: We aimed to use genetic data to study whether these 2 disorders are causally linked or share genetic architecture. METHODS: We performed two-sample Mendelian randomization and linkage disequilibrium score regression using summary statistics from recent genome-wide meta-analyses of PD and restless legs syndrome. RESULTS: We found no evidence for a causal relationship between restless legs syndrome (as the exposure) and PD (as the outcome, inverse variance-weighted; b = -0.003, SE = 0.031, P = 0.916; F statistic = 217.5). Reverse Mendelian randomization also did not demonstrate any causal effect of PD on restless legs syndrome (inverse variance-weighted; b = -0.012, SE = 0.023, P = 0.592; F statistic = 191.7). Linkage disequilibrium score regression analysis demonstrated lack of genetic correlation between restless legs syndrome and PD (rg = -0.028, SE = 0.042, P = 0.507). CONCLUSIONS: There was no evidence for a causal relationship or genetic correlation between restless legs syndrome and PD. The associations observed in epidemiological studies could be attributed, in part, to confounding or nongenetic determinants. © 2021 International Parkinson and Movement Disorder Society.","journal":"Movement Disorders","year":2021,"id":190907,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9591,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":297178,"name":"Konstantin Senkevich","orcid":"0000-0003-3407-5716","position":1,"is_corresponding":false},{"id":347907,"name":"Eric Yu","orcid":"0000-0003-3525-4564","position":2,"is_corresponding":false},{"id":756510,"name":"Parizad Varghaei","orcid":null,"position":3,"is_corresponding":false},{"id":279271,"name":"Lynne Krohn","orcid":"0000-0001-6554-1666","position":4,"is_corresponding":false},{"id":230757,"name":"Sara Bandrés‐Ciga","orcid":"0000-0003-0056-1361","position":5,"is_corresponding":false},{"id":80307,"name":"Alastair J. Noyce","orcid":"0000-0003-3027-5497","position":6,"is_corresponding":false},{"id":53271,"name":"Guy A. Rouleau","orcid":"0000-0001-8403-1418","position":7,"is_corresponding":false},{"id":263848,"name":"Ziv Gan‐Or","orcid":"0000-0003-0332-234X","position":8,"is_corresponding":false},{"id":354248,"name":"Mehrdad A. Estiar","orcid":"0000-0002-1579-6342","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-18T23:49:31.121780Z","pmid":"33974305","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}