{"doi":"10.1002/mds.28494","title":"<scp>GP2</scp>: The Global Parkinson's Genetics Program","abstract":"Fundamentally, the identification of causes and contributors of disease represents the first step in an etiology-based understanding of disease. This, in turn, is a required step in the development of therapeutics targeting the underlying disease process. Parkinson's disease (PD) is believed to be a complex disorder, with disease liability driven in part by genetics. Current heritability estimates suggest that common genetic variability contributes ~22% of the disease liability in an average patient.1 Although this is believed to be an underestimate, it is also likely that there are nongenetic influences, such as environmental exposure or stochastic events. Genetics, however, has shown itself to be a robust, tractable, and reliable method to understand disease biology. Genetic understanding serves as a foundation for succeeding functional studies and as a central component of efforts to predict disease risk, onset, and progression and to understand disease mechanisms in individual patients. Without a reliable and complete foundation of genetic understanding, we limit our ability to develop and deploy treatments. A large number of risk loci and causative mutations for PD have been identified; however, it is clear that the majority of genetic risk remains to be found.1, 2 Although much can be done with existing knowledge, moving forward now to expand our genetic understanding will be the foundation that will support the development of a complete view of this network, providing an array of potential therapeutic opportunities. Increasing genetic information can only serve to improve our efforts to treat disease. Notably, our understanding of the genetic basis of PD has thus far largely been centered on research in individuals of northern European ancestry. Although some genetic discoveries have been made outside these populations, this work is the exception rather than the norm and generally focuses on the identification of rare mutations; little has been done in the identification of more common genes or genetic risk discovery.3, 4 Thus, we do not know if our current understanding is generalizable to the rest of the world and how the basis of disease varies across populations. Although it is tempting to argue that the genetic basis for PD will generally be the same across populations, we know that differences in genetic risk exist, and furthermore, there is evidence to suggest that genetic forms of disease can present differently across populations.3, 5-8 This fundamental limitation of current research creates an inequitable situation for patients. To facilitate the rapid expansion of our understanding of the genetic architecture of PD, both in terms of the depth and global context of this knowledge, we have created the Global Parkinson's Genetics Program (GP2; www.gp2.org). GP2 is the first supported resource project of the Aligning Science Across Parkinson's (ASAP) initiative, an audacious effort supporting PD research.9 GP2 is geared toward creating a worldwide collaborative effort that will first dramatically accelerate the identification of genetic contributors to disease and second establish a network of researchers who can best leverage this understanding to research, diagnose, and treat PD worldwide. Here we describe our mission, the path we have proposed to achieve this, and the core principles of data democratization, transparency, and diversity. The mission of GP2 is to drive transformational progress in our understanding of the genetic architecture of PD and to serve as a useful and actionable resource for the research and therapeutic development community. To fully realize this mission, GP2 will need to engage and mobilize a worldwide community of researchers and participants, generate and analyze genetic data on an extremely large scale, create an infrastructure that removes obstacles to data access, and make data and results accessible and useful to the broader community (Fig. 1). Broadly, there are 2 scientific ar","journal":"Movement Disorders","year":2021,"id":147197,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":170,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9529,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":627043,"name":"The Global Parkinson's Genetics Program","orcid":null,"position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-18T23:42:30.206628Z","pmid":"33513272","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}