{"doi":"10.1002/mds.28129","title":"Subclinical Cardiac Microdamage, Motor Severity, and Cognition in Parkinson's Disease","abstract":"BACKGROUND: We assessed if cardiac blood markers are associated with motor and cognitive function in patients with Parkinson's disease (PD). METHODS: High-sensitivity troponin I and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were evaluated in 285 PD patients. Furthermore, N-terminal pro-B-type natriuretic peptide levels were analyzed in 570 age, sex and cardiovascular risk factor matched healthy controls. Motor (UPDRS, Hoehn &Yahr) and cognitive function (Montreal Cognitive Assessemtn) were assessed at baseline in all 285 patients and after 1 year in 101 patients. RESULTS: N-terminal pro-B-type natriuretic peptide were significantly increased in 285 PD patients compared with 570 matched healthy controls. In PD patients, increased high-sensitivity troponin I and N-terminal pro-B-type natriuretic peptide levels were associated with worse motor function at baseline and also with motor decline after 1 year. N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin I were inversely associated with cognitive function at baseline only in unadjusted models. CONCLUSIONS: Subclinical cardiac microdamage is associated with motor severity in PD patients. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.","journal":"Movement Disorders","year":2020,"id":68395,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9539,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":362173,"name":"Louisa Niemann","orcid":"0000-0002-1584-8632","position":1,"is_corresponding":false},{"id":363103,"name":"Catrin Englisch","orcid":null,"position":2,"is_corresponding":false},{"id":362174,"name":"Elina Petersen","orcid":"0000-0002-1235-5066","position":3,"is_corresponding":false},{"id":362175,"name":"Carsten Buhmann","orcid":"0000-0001-8540-3789","position":4,"is_corresponding":false},{"id":362176,"name":"Monika Pötter‐Nerger","orcid":"0000-0001-7680-2147","position":5,"is_corresponding":false},{"id":240632,"name":"Stefan Blankenberg","orcid":"0000-0001-6488-2362","position":6,"is_corresponding":false},{"id":249947,"name":"Christian Gerloff","orcid":"0000-0002-6484-8882","position":7,"is_corresponding":false},{"id":362177,"name":"Edzard Schwedhelm","orcid":"0000-0003-3597-6276","position":8,"is_corresponding":false},{"id":362178,"name":"Tanja Zeller","orcid":"0000-0003-3379-2641","position":9,"is_corresponding":false},{"id":249965,"name":"Chi‐un Choe","orcid":"0000-0002-9154-8439","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-18T21:40:52.680475Z","pmid":"32557851","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}