{"doi":"10.1002/mdc3.70357","title":"Quantitative Susceptibility Mapping and Iron Deposition in Autopsy‐Confirmed Progressive Supranuclear Palsy","abstract":"BACKGROUND: Quantitative susceptibility mapping (QSM) is a promising neuroimaging biomarker for detecting abnormal iron deposition in progressive supranuclear palsy (PSP); however, the QSM profile and its accuracy in autopsy-confirmed PSP remain unexplored. OBJECTIVE: The aim of the study was to elucidate and validate the QSM profiles in autopsy-confirmed PSP. METHODS: Eight patients with a clinically diagnosed PSP syndrome (PSPS) underwent antemortem 3 T magnetic resonance imaging (MRI) scanning and subsequent pathological diagnosis, confirming 6 PSP pathology and 2 multiple system atrophy (MSA) pathology cases. QSM analysis and Prussian blue staining were performed across subcortical regions. RESULTS: PSP cases showed higher susceptibility than age-matched controls in the pallidum, subthalamic nucleus, substantia nigra, and cerebellar dentate (false discovery rate [FDR]-corrected P < 0.05). PSP had higher susceptibility in the subthalamic nucleus and lower susceptibility in the putamen than the clinically atypical MSA (P = 0.08). Subcortical susceptibilities correlated with Prussian blue-stained areas (r = 0.63, P < 0.001). CONCLUSIONS: QSM could be a reliable measure to evaluate abnormal iron accumulation patterns in PSP.","journal":"Movement Disorders Clinical Practice","year":2025,"id":575079,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7799,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":618447,"name":"Hiroaki Sekiya","orcid":"0000-0001-9683-5966","position":1,"is_corresponding":false},{"id":383666,"name":"Farwa Ali","orcid":"0000-0001-6060-3995","position":2,"is_corresponding":false},{"id":54753,"name":"Dennis W. Dickson","orcid":"0000-0001-7189-7917","position":3,"is_corresponding":false},{"id":271235,"name":"Jennifer L. Whitwell","orcid":"0000-0001-6914-1563","position":4,"is_corresponding":false},{"id":238177,"name":"Keith A. Josephs","orcid":"0000-0003-2930-8634","position":5,"is_corresponding":false},{"id":1052259,"name":"Ryota Satoh","orcid":"0000-0002-3418-2987","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T02:57:48.486077Z","pmid":"40960890","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}