{"doi":"10.1002/mdc3.14188","title":"Lateralized Subthalamic Stimulation for Axial Dysfunction in Parkinson's Disease: Exploratory Outcomes and Open‐Label Extension","abstract":"BACKGROUND: A randomized trial suggested that reducing left-sided subthalamic stimulation amplitude could improve axial dysfunction. OBJECTIVES: To explore open-label tolerability and associations between trial outcomes and asymmetry data. METHODS: We collected adverse events in trial participants treated with open-label lateralized settings for ≥3 months. We explored associations between trial outcomes, location of stimulation and motor asymmetry. RESULTS: 14/17 participants tolerated unilateral amplitude reduction (left-sided = 10, right-sided = 4). Two hundred eighty-four left-sided and 1113 right-sided stimulated voxels were associated with faster gait velocity, 81 left-sided and 22 right-sided stimulated voxels were associated with slower gait velocity. Amplitude reduction contralateral to shorter step length was associated with 2.4-point reduction in axial MDS-UPDRS. Reduction contralateral to longer step length was associated with 10-point increase in MDS-UPDRS. CONCLUSIONS: Left-sided amplitude reduction is potentially more tolerable than right-sided amplitude reduction. Right-sided more than left-sided stimulation could be associated with faster gait velocity. Shortened step length might reflect contralateral overstimulation.","journal":"Movement Disorders Clinical Practice","year":2024,"id":445275,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.963,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1261722,"name":"Bhairavei Gnanamanogaran","orcid":null,"position":1,"is_corresponding":false},{"id":1261231,"name":"Tameem M. Al‐Ozzi","orcid":"0000-0002-1800-7935","position":2,"is_corresponding":false},{"id":1261232,"name":"Mélanie Cohn","orcid":"0000-0003-2921-7505","position":3,"is_corresponding":false},{"id":272520,"name":"George Tomlinson","orcid":"0000-0002-9328-6399","position":4,"is_corresponding":false},{"id":232899,"name":"Alexandre Boutet","orcid":"0000-0001-6942-5195","position":5,"is_corresponding":false},{"id":232898,"name":"Gavin J.B. Elias","orcid":"0000-0002-7495-550X","position":6,"is_corresponding":false},{"id":550195,"name":"Jürgen Germann","orcid":"0000-0003-0995-8226","position":7,"is_corresponding":false},{"id":1261233,"name":"Derrick Soh","orcid":"0000-0003-1328-2775","position":8,"is_corresponding":false},{"id":560335,"name":"Suneil K. Kalia","orcid":"0000-0003-2054-1915","position":9,"is_corresponding":false},{"id":708857,"name":"Mojgan Hodaie","orcid":"0000-0001-6278-4929","position":10,"is_corresponding":false},{"id":301283,"name":"Renato P. Munhoz","orcid":"0000-0002-4783-4067","position":11,"is_corresponding":false},{"id":341997,"name":"Connie Marras","orcid":"0000-0002-9236-9328","position":12,"is_corresponding":false},{"id":1261234,"name":"William D. Hutchison","orcid":"0000-0002-3866-4940","position":13,"is_corresponding":false},{"id":232900,"name":"Andrés M. Lozano","orcid":"0000-0001-8257-3694","position":14,"is_corresponding":false},{"id":17424,"name":"Anthony E. Lang","orcid":"0000-0003-1229-3667","position":15,"is_corresponding":false},{"id":263851,"name":"Alfonso Fasano","orcid":"0000-0001-5346-0180","position":16,"is_corresponding":false},{"id":317510,"name":"Karlo J. Lizárraga","orcid":"0000-0001-9766-6252","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T02:01:42.089235Z","pmid":"39136363","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}