{"doi":"10.1002/mdc3.14048","title":"Early Screening for the Parkinson Variant of Multiple System Atrophy: A 6‐Item Score","abstract":"BACKGROUND: A 4-item score based on ≥2 features out of orthostatic hypotension, overactive bladder, urinary retention and postural instability was previously shown to early distinguish the Parkinson-variant of multiple system atrophy (MSA-P) from Parkinson's disease (PD) with 78% sensitivity and 86% specificity. OBJECTIVES: To replicate and improve the 4-item MSA-P score. METHODS: We retrospectively studied 161 patients with early parkinsonism [ie, ≤2 years disease duration or no postural instability, aged 64 (57; 68) years, 44% females] and a diagnosis of clinically established MSA-P (n = 38) or PD (n = 123) after ≥24 months follow-up. RESULTS: The 4-item MSA-P score had a 92% sensitivity and 78% specificity for a final MSA-P diagnosis. By including dopaminergic responsiveness and postural deformities into a 6-item score (range: 0-6), reaching ≥3 points at early disease identified MSA-P patients with 89% sensitivity and 98% specificity. CONCLUSIONS: The 6-item MSA-P score is a cost-effective tool to pinpoint individuals with early-stage MSA-P.","journal":"Movement Disorders Clinical Practice","year":2024,"id":448565,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8244,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":669900,"name":"Iva Stanković","orcid":"0000-0003-1484-4717","position":1,"is_corresponding":false},{"id":1267967,"name":"Omer Avraham","orcid":null,"position":2,"is_corresponding":false},{"id":227416,"name":"Milica Ječmenica‐Lukić","orcid":"0000-0003-4255-7192","position":3,"is_corresponding":false},{"id":1267968,"name":"Adi Ezra","orcid":null,"position":4,"is_corresponding":false},{"id":1207697,"name":"Fabian Leys","orcid":"0000-0003-1714-5305","position":5,"is_corresponding":false},{"id":1267969,"name":"Georg Goebel","orcid":null,"position":6,"is_corresponding":false},{"id":348670,"name":"Florian Krismer","orcid":"0000-0002-4493-5073","position":7,"is_corresponding":false},{"id":1267508,"name":"Igor Petrović","orcid":"0000-0003-2669-8251","position":8,"is_corresponding":false},{"id":1204599,"name":"Marina Svetel","orcid":"0000-0003-4900-4865","position":9,"is_corresponding":false},{"id":348662,"name":"Klaus Seppi","orcid":"0000-0001-6503-1455","position":10,"is_corresponding":false},{"id":750789,"name":"Vladimir Kostić","orcid":"0000-0002-0184-9802","position":11,"is_corresponding":false},{"id":388724,"name":"Nir Giladi","orcid":"0000-0003-1482-8522","position":12,"is_corresponding":false},{"id":92184,"name":"Werner Poewe","orcid":"0000-0003-4367-0971","position":13,"is_corresponding":false},{"id":367442,"name":"Gregor K. Wenning","orcid":"0000-0001-9077-1666","position":14,"is_corresponding":false},{"id":1267509,"name":"Tanya Gurevich","orcid":"0000-0003-2092-9848","position":15,"is_corresponding":false},{"id":669897,"name":"Alessandra Fanciulli","orcid":"0000-0002-2854-4179","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T02:02:12.215092Z","pmid":"38659282","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}