{"doi":"10.1002/mco2.70354","title":"Plasmacytoid and CD141+ Myeloid Dendritic Cells Cooperation with CD8+ T Cells in Lymph Nodes is Associated with HIV Control","abstract":"Dendritic cells (DC) are known to modulate antiviral immune responses; however, the knowledge about the role of different DC subsets in antiviral T cell priming in human tissues remains uncompleted. In the context of HIV infection, we determined the phenotype and location of plasmacytoid and CD141+ myeloid DCs (pDCs and mDCs) in lymph nodes of people living with HIV (PLWH). We found an interaction between pDCs and CD141+ mDCs with CD8+ T cells, being associated with participants' viral levels in blood and tissue. Moreover, we demonstrated a higher and more polyfunctional superantigen- and HIV-specific CD8+ T cell response after the coculture with Toll-like receptor (TLR)-primed pDCs and CD141+ mDCs. Last, we showed the potential of programmed cell death-1 (PD-1) blocking using pembrolizumab to further increase antigen-specific CD8+ T cell response along with TLR agonists. Therefore, these results showed a cooperation between pDCs, CD141+ mDCs and CD8+ T cells in lymph nodes of PLWH, which is associated with higher HIV control, highlighting the importance of DC subsets crosstalk to achieve a more potent anti-HIV response and support the use of DC-based immunotherapies for HIV control.","journal":"MedComm","year":2025,"id":574827,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9583,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":818968,"name":"Sara Bachiller","orcid":"0000-0002-9000-3787","position":1,"is_corresponding":false},{"id":1482851,"name":"Beatriz Domínguez-Molina","orcid":null,"position":2,"is_corresponding":false},{"id":406188,"name":"Eirini Moysi","orcid":"0000-0002-2070-2902","position":3,"is_corresponding":false},{"id":353333,"name":"Sara Ferrando‐Martínez","orcid":"0000-0003-0721-555X","position":4,"is_corresponding":false},{"id":1222545,"name":"María Inés Camacho-Sojo","orcid":null,"position":5,"is_corresponding":false},{"id":1222034,"name":"Isabel Gallego","orcid":"0000-0002-7338-1778","position":6,"is_corresponding":false},{"id":818959,"name":"Alberto Pérez‐Gómez","orcid":"0000-0002-3644-2914","position":7,"is_corresponding":false},{"id":818967,"name":"María Reyes Jiménez‐León","orcid":"0000-0003-2723-319X","position":8,"is_corresponding":false},{"id":1222033,"name":"Carmen Gasca‐Capote","orcid":"0000-0002-7211-8599","position":9,"is_corresponding":false},{"id":818961,"name":"Francisco José Ostos","orcid":"0000-0001-6583-6974","position":10,"is_corresponding":false},{"id":818970,"name":"Mohammed Rafii‐El‐Idrissi Benhnia","orcid":"0000-0001-7405-9476","position":11,"is_corresponding":false},{"id":584801,"name":"Laura E. Via","orcid":"0000-0001-6074-9521","position":12,"is_corresponding":false},{"id":1482852,"name":"Antonio Mochón","orcid":null,"position":13,"is_corresponding":false},{"id":818971,"name":"Luís F. López‐Cortés","orcid":"0000-0002-3804-3458","position":14,"is_corresponding":false},{"id":406189,"name":"Constantinos Petrovas","orcid":"0000-0002-5067-5810","position":15,"is_corresponding":false},{"id":290824,"name":"Richard A. Koup","orcid":"0000-0002-3090-7282","position":16,"is_corresponding":false},{"id":400482,"name":"Ezequiel Ruíz-Mateos","orcid":"0000-0001-6747-7813","position":17,"is_corresponding":false},{"id":818960,"name":"Joana Vitallé","orcid":"0000-0002-5292-1851","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T02:57:44.572630Z","pmid":"40949488","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}