{"doi":"10.1002/mc.23730","title":"Deciphering CD4<sup>+</sup> T cell‐mediated responses against cancer","abstract":"Abstract It's been long thought that CD8 + cytotoxic T cells play a major role in T cell‐mediated antitumor responses, whereas CD4 + T cells merely provide some assistance to CD8 + T cells as the “helpers.” In recent years, numerous studies support the notion that CD4 + T cells play an indispensable role in antitumor responses. Here, we summarize and discuss the current knowledge regarding the roles of CD4 + T cells in antitumor responses and immunotherapy, with a focus on the molecular and cellular mechanisms behind these observations. These new insights on CD4 + T cells may pave the way to further optimize cancer immunotherapy.","journal":"Molecular Carcinogenesis","year":2024,"id":457605,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9475,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":585528,"name":"Yong‐Chen Lu","orcid":"0000-0002-0275-9825","position":1,"is_corresponding":false},{"id":537960,"name":"Catherine Kirkpatrick","orcid":"0009-0000-4955-2410","position":0,"is_corresponding":true}],"reference_count":142,"raw_metadata":null,"created_at":"2026-07-19T02:03:41.744499Z","pmid":"38725218","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}