{"doi":"10.1002/mc.10169","title":"Crossregulation of NF‐κB by the APC/GSK‐3β/β‐catenin pathway","abstract":"<jats:title>Abstract</jats:title><jats:p>Glycogen synthase kinase‐3β (GSK‐3β) and adenomatous polyposis coli (APC) play an important role in the regulation of β‐catenin. Inhibition of or defects in their functions can lead to activation of β‐catenin. β‐catenin has been recently found to interact with and inhibit nuclear factor kappa B (NF‐κB). However, the regulatory roles of GSK‐3β/APC on the NF‐κB signaling pathway are unknown because of their diverse effects. In this study, we investigated whether GSK‐3β/APC might regulate NF‐κB activity through β‐catenin. We found that inhibition of GSK‐3β suppressed NF‐κB activity, whereas reexpression of APC restored NF‐κB activity in APC mutated cells. The regulatory effects were through β‐catenin because depletion of β‐catenin with small interfering RNA (siRNA) in the same systems reversed the effects. The regulatory relationship was further supported by the analysis of primary breast tumor tissues in vivo in which NF‐κB target TRAF1 was inversely correlated with activated β‐catenin. Thus, APC/GSK‐3β, through β‐catenin, may crossregulate NF‐κB signaling pathway. © 2004 Wiley‐Liss, Inc.</jats:p>","journal":"Molecular Carcinogenesis","year":2004,"id":21374,"datarank":5.498091738128904,"base_score":4.442651256490317,"endowment":4.442651256490317,"self_citation_contribution":0.6663976884735476,"citation_network_contribution":4.831694049655357,"self_endowment_contribution":0.6663976884735476,"citer_contribution":4.831694049655357,"corpus_percentile":null,"corpus_rank":null,"citation_count":84,"citer_count":83,"citers_with_citation_signal":79,"citers_with_endowment":79,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":107243,"name":"Weiya Xia","orcid":null,"position":1,"is_corresponding":false},{"id":137854,"name":"Stephanie A. Miller","orcid":null,"position":2,"is_corresponding":false},{"id":137856,"name":"Yong Wen","orcid":null,"position":3,"is_corresponding":false},{"id":137858,"name":"Hong‐Ying Wang","orcid":null,"position":4,"is_corresponding":false},{"id":107263,"name":"Mien‐Chie Hung","orcid":"0000-0003-4317-4740","position":5,"is_corresponding":false},{"id":137851,"name":"Jiong Deng","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.442651256490317,"endowment":4.442651256490317,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"14991743","pmcid":null,"openalex_id":"https://openalex.org/W1843940622","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"R01 CA58880","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P01 CA099031","title":null}],"total_grants":2,"fwci":2.9186,"citation_percentile":0.908531,"influential_citations":0,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":5},{"year":2014,"count":2},{"year":2015,"count":3},{"year":2016,"count":4},{"year":2017,"count":4},{"year":2018,"count":3},{"year":2019,"count":4},{"year":2020,"count":4},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2024,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmc.10169","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/mc.10169","host_type":"publisher"},{"url":"https://doi.org/10.1002/mc.10169","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/14991743","host_type":"repository"}],"fields_of_study":["NF-κB Signaling Pathways","Wnt/β-catenin signaling in development and cancer","Cancer-related gene regulation","Biology","Medicine","Adenomatous Polyposis Coli Protein","Cell Line, Tumor","Cytoskeletal Proteins","Electrophoretic Mobility Shift Assay","Glycogen Synthase Kinase 3","Glycogen Synthase Kinase 3 beta","Humans","Immunohistochemistry","NF-kappa B","Trans-Activators","beta Catenin"],"mesh_terms":["Glycogen Synthase Kinase 3 beta","Cytoskeletal Proteins","Humans","Immunohistochemistry","Trans-Activators","NF-kappa B","Electrophoretic Mobility Shift Assay","Adenomatous Polyposis Coli Protein","Glycogen Synthase Kinase 3","Cell Line, Tumor","beta Catenin"],"keywords":["GSK-3","Biology","Catenin","Adenomatous polyposis coli","Wnt signaling pathway","NF-κB","Small interfering RNA","Glycogen synthase","Beta-catenin","Signal transduction","NFKB1","Cancer research","Cell biology","Phosphorylation","Transcription factor","RNA","Biochemistry","Genetics","Gene","Colorectal cancer","Cancer"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-06T15:41:33.303597Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}