{"doi":"10.1002/lt.21744","title":"Survival After Liver Transplantation for Hepatocellular Carcinoma in the Model for End-Stage Liver Disease and Pre–Model for End-Stage Liver Disease Eras and the Independent Impact of Hepatitis C Virus","abstract":"<jats:title>\n                           <jats:bold>Abstract</jats:bold>\n                        </jats:title>\n          <jats:sec>\n            <jats:title/>\n            <jats:p>It has been suggested that hepatitis C virus (HCV) patients with hepatocellular carcinoma (HCC) may have worse outcomes after liver transplantation (LT) because of more aggressive tumor biology. In this study, we determined the post-LT survival of HCC patients with and without HCV using United Network for Organ Sharing data from January 1994 to March 2008. Patients with HCC were stratified into HCV (HCC-HCV) and non-HCV (HCC–non-HCV) groups. In the era before the Model for End-Stage Liver Disease (MELD), there were 1237 HCC patients (780, HCV; 373, non-HCV; 84, unknown HCV status), and during the MELD era, there were 4933 HCC patients (3272, HCV; 1348, non-HCV; 313, unknown). In the pre-MELD era, 5-year graft (58.6% versus 53.7%) and patient (61.7% versus 59.3%) survival rates were marginally higher for HCC–non-HCV patients than for HCC-HCV patients. In the MELD era also, 5-year graft (61.2% versus 55.5%) and patient (63.7% versus 58.2%) survival rates were marginally higher for HCC–non-HCV patients than for HCC-HCV patients. In patients without HCC, pre-MELD and MELD era graft/patient survival rates for non-HCV patients were higher than those for HCV patients. The differences in survival rates for HCC patients with and without HCV were lower than those for non-HCC patients stratified by their HCV status. HCV had no additional negative impact on the post-LT survival of patients with HCC, and this was further confirmed by multivariate analysis. In conclusion, the survival of HCC patients has remained unchanged in the past 2 decades. HCV patients have a lower survival rate than non-HCV patients, regardless of their HCC status, but HCV has no additional negative impact on survival in patients with HCC. Liver Transpl 15:754–762, 2009. © 2009 AASLD.</jats:p>\n          </jats:sec>","journal":"Liver Transplantation","year":2009,"id":26059,"datarank":1.5850500346122074,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":1.096335553908985,"self_endowment_contribution":0.4887144807032224,"citer_contribution":1.096335553908985,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":25,"citers_with_citation_signal":19,"citers_with_endowment":19,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":151694,"name":"Anurag Maheshwari","orcid":null,"position":1,"is_corresponding":false},{"id":151695,"name":"Nimisha P. Thuluvath","orcid":null,"position":2,"is_corresponding":false},{"id":151696,"name":"Geoffrey C. Nguyen","orcid":null,"position":3,"is_corresponding":false},{"id":151697,"name":"Dorry L. Segev","orcid":null,"position":4,"is_corresponding":false},{"id":151693,"name":"Paul J. Thuluvath","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19562709","pmcid":null,"openalex_id":"https://openalex.org/W1979664732","authors":[],"funders":[],"total_grants":0,"fwci":2.0775,"citation_percentile":0.86621277,"influential_citations":2,"citation_trend":[{"year":2012,"count":5},{"year":2013,"count":3},{"year":2015,"count":3},{"year":2017,"count":3},{"year":2018,"count":1},{"year":2020,"count":1}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/lt.21744","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/lt.21744","host_type":"HYBRID"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/lt.21744","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Flt.21744","host_type":"publisher"},{"url":"https://journals.lww.com/01445473-200907000-00012","host_type":"publisher"},{"url":"https://doi.org/10.1002/lt.21744","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19562709","host_type":"repository"}],"fields_of_study":["Hepatitis C virus research","Liver Disease Diagnosis and Treatment","Hepatocellular Carcinoma Treatment and Prognosis","Medicine","Aged","Carcinoma, Hepatocellular","Female","Hepacivirus","Hepatitis C","Humans","Liver Failure","Liver Neoplasms","Liver Transplantation","Male","Middle Aged","Multivariate Analysis","Time Factors","Treatment Outcome","Waiting Lists"],"mesh_terms":["Aged","Female","Hepatitis C","Carcinoma, Hepatocellular","Humans","Liver Neoplasms","Male","Middle Aged","Time Factors","Waiting Lists","Multivariate Analysis","Liver Transplantation","Hepacivirus","Treatment Outcome","Liver Failure"],"keywords":["Medicine","Hepatocellular carcinoma","Hepatitis C virus","Liver transplantation","Internal medicine","Hepatitis C","Gastroenterology","Liver disease","Model for End-Stage Liver Disease","Stage (stratigraphy)","Survival rate","Transplantation","Immunology","Virus"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-08T11:05:42.817842Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}