{"doi":"10.1002/lipd.12218","title":"Assembly and Characterization of Biocompatible Coenzyme Q<sub>10</sub>‐Enriched Lipid Nanoparticles","abstract":"Abstract Coenzyme Q 10 (CoQ 10 ) is a strongly hydrophobic lipid that functions in the electron transport chain and as an antioxidant. CoQ 10 was conferred with aqueous solubility by incorporation into nanoparticles containing phosphatidylcholine (PtdCho) and apolipoprotein (apo) A‐I. These particles, termed CoQ 10 nanodisks (ND), contain 1.0 mg CoQ 10 /5 mg PtdCho/2 mg apoA‐I (97% CoQ 10 solubilization efficiency). UV/Vis absorbance spectroscopy of CoQ 10 ND revealed a characteristic absorbance peak centered at 275 nm. Incorporation of CoQ 10 into ND resulted in quenching of apoA‐I tryptophan fluorescence emission. Gel filtration chromatography of CoQ 10 ND gave rise to a single major absorbance peak and HPLC of material extracted from this peak confirmed the presence of CoQ 10 . Incubation of cultured cells with CoQ 10 ND, but not empty ND, resulted in a significant increase in the CoQ 10 content of mitochondria as well as enhanced oxidative phosphorylation, as observed by a ~24% increase in maximal oxygen consumption rate. Collectively, a facile method to solubilize significant quantities of CoQ 10 in lipid nanoparticles has been developed. The availability of CoQ 10 ND provides a novel means to investigate biochemical aspects of CoQ 10 uptake by cells and/or administer it to subjects deficient in this key lipid as a result of inborn errors of metabolism, statin therapy, or otherwise.","journal":"Lipids","year":2020,"id":86778,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.966,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":442906,"name":"Lucas N. Vine","orcid":null,"position":1,"is_corresponding":false},{"id":442907,"name":"Kyle Lethcoe","orcid":null,"position":2,"is_corresponding":false},{"id":409474,"name":"Ruben K. Dagda","orcid":"0000-0002-9946-9591","position":3,"is_corresponding":false},{"id":442908,"name":"Patricia Ellison","orcid":null,"position":4,"is_corresponding":false},{"id":442024,"name":"Robert O. Ryan","orcid":"0000-0002-6739-5903","position":5,"is_corresponding":false},{"id":442905,"name":"Anthony Moschetti","orcid":null,"position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-18T21:59:03.706190Z","pmid":"32074388","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}