{"doi":"10.1002/lary.32471","title":"Acid Suppression in Mild‐Moderate Laryngomalacia Without <scp>GERD</scp> : A Randomized Controlled Trial","abstract":"OBJECTIVE: To determine the efficacy of acid suppression therapy (AST) for the treatment of gastroesophageal reflux (GER) and airway symptoms in infants with mild to moderate laryngomalacia. METHODS: From 2020 to 2023, infants ≤ 6 months old with laryngomalacia at a tertiary children's hospital were randomized to famotidine and feeding modifications (AST) or feeding modifications alone (no-AST). Laryngomalacia Airway Symptom Score (LASS) and Infant Gastroesophageal Reflux Questionnaire (I-GERQ-R) were completed by guardians. Of 343 patients approached, 257 were excluded due to severe laryngomalacia on LASS, severe GER (I-GERQ-R ≥ 16), prior AST, no laryngomalacia on laryngoscopy, recommendation for supraglottoplasty, and/or other airway anomalies. Twenty-one declined participation. LASS and I-GERQ-R were again completed 1-6 months following enrollment. RESULTS: Sixty-five patients enrolled; 40/65 (62%) followed up at a mean of 3.1 months (SD 1.4 months). Of these 40, 10 (25%) had mild and 30 (75%) had moderate laryngomalacia. Median I-GERQ-R was 11 (range 5-15) at the initial appointment and 7.5 (range 0-26) at follow-up (p = 0.002). Laryngomalacia resolved in 13/40 (33%) at follow-up based on LASS (p < 0.001). Patients randomized to AST (n = 20) and no-AST (n = 20) had comparable improvement on LASS (p = 0.3) and I-GERQ-R (p = 0.8). Additionally, the severity of laryngomalacia at initial consult did not have a significant impact on LASS (p = 0.3) or I-GERQ-R (p = 0.8) improvement. LASS (ρ = 0.423, p = 0.007) but not I-GERQ-R (ρ = 0.122, p = 0.5) improved more with longer time from consult to follow-up. CONCLUSION: This small randomized controlled trial was unable to demonstrate additional benefit from AST compared to feeding modifications alone based on airway and reflux symptoms. TRIAL REGISTRATION: https://clinicaltrials.gov/study/NCT04614974.","journal":"The Laryngoscope","year":2025,"id":545795,"datarank":0.13670402727710035,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.032731950193108525,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.032731950193108525,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9634,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT04614974"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1005626,"name":"Zainab Balogun","orcid":"0000-0001-6695-4294","position":1,"is_corresponding":false},{"id":443084,"name":"Allison B.J. Tobey","orcid":"0000-0002-7988-1706","position":2,"is_corresponding":false},{"id":443083,"name":"Raymond C. Maguire","orcid":"0000-0002-2276-0305","position":3,"is_corresponding":false},{"id":284536,"name":"Jeffrey S. Simons","orcid":"0000-0002-6378-0281","position":4,"is_corresponding":false},{"id":453502,"name":"Joseph E. Dohar","orcid":"0000-0002-9482-4195","position":5,"is_corresponding":false},{"id":443082,"name":"Jennifer L. McCoy","orcid":"0000-0003-2217-4493","position":6,"is_corresponding":false},{"id":1418542,"name":"Marina V Rushchak","orcid":null,"position":7,"is_corresponding":false},{"id":949231,"name":"Reema Padia","orcid":"0000-0002-5876-7816","position":8,"is_corresponding":false},{"id":390012,"name":"Amber D. Shaffer","orcid":"0000-0001-5783-9198","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":null,"created_at":"2026-07-19T02:53:27.751050Z","pmid":"40762274","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}