{"doi":"10.1002/lary.31868","title":"Prostaglandin E Receptor 2 (<scp>EP2</scp>) Dysregulation in Allergic Fungal Rhinosinusitis Nasal Polyp Epithelium","abstract":"OBJECTIVES: Allergic fungal rhinosinusitis (AFRS) is an eosinophilic subtype of chronic rhinosinusitis with nasal polyposis (CRSwNP). This study aimed to investigate the transcriptome of AFRS nasal polyp epithelium. METHODS: Sinonasal epithelial cells were harvested from healthy nasal mucosa and polyp tissue collected from participants undergoing elective sinonasal surgery. Primary epithelial cells were subsequently grown in air/liquid interface and subjected to RNA-seq analysis, RT-qPCR, immunoblotting, and immunostaining. RESULTS: A total of 19 genes were differentially expressed between healthy and AFRS sample epithelium. The second top candidate gene, ranked by adjusted p-value, was prostaglandin E receptor 2 (PTGER2). The upregulation of PTGER2 was confirmed by RT-qPCR and immunoblot. The presence of the EP2 receptor, encoded by the PTGER2 gene, was confirmed by immunocytochemistry. CONCLUSION: PTGER2 is a potential novel therapeutic target for AFRS. EP2 dysregulation is associated with aspirin-exacerbated respiratory disease, potentially giving insight into common mechanisms of disease in severe CRSwNP. LEVEL OF EVIDENCE: NA Laryngoscope, 135:S1-S8, 2025.","journal":"The Laryngoscope","year":2024,"id":477872,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9428,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1316451,"name":"Khaled A. Altartoor","orcid":null,"position":1,"is_corresponding":false},{"id":373856,"name":"Mbuyi Madeleine Kabongo","orcid":"0000-0002-5158-6860","position":2,"is_corresponding":false},{"id":879579,"name":"Henry Claussen","orcid":"0009-0002-7893-6514","position":3,"is_corresponding":false},{"id":787793,"name":"Robert A. Arthur","orcid":"0000-0003-4824-4971","position":4,"is_corresponding":false},{"id":263877,"name":"H. Richard Johnston","orcid":"0000-0001-5668-1093","position":5,"is_corresponding":false},{"id":336426,"name":"John M. DelGaudio","orcid":"0000-0003-0132-8545","position":6,"is_corresponding":false},{"id":660746,"name":"Sarah K. Wise","orcid":"0000-0002-6398-0056","position":7,"is_corresponding":false},{"id":660745,"name":"C. Arturo Solares","orcid":"0000-0002-2794-5034","position":8,"is_corresponding":false},{"id":336424,"name":"Emily Barrow","orcid":"0000-0002-9034-3167","position":9,"is_corresponding":false},{"id":70192,"name":"Kelly R. Magliocca","orcid":"0000-0002-3520-9694","position":10,"is_corresponding":false},{"id":264691,"name":"Michael Koval","orcid":"0000-0002-5422-5614","position":11,"is_corresponding":false},{"id":336427,"name":"Joshua M. Levy","orcid":"0000-0001-5907-3421","position":12,"is_corresponding":false},{"id":1001878,"name":"Prestina Smith","orcid":"0000-0001-5673-3279","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T02:06:37.812633Z","pmid":"39487665","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}