{"doi":"10.1002/lary.30585","title":"<scp>Corticosteroid‐LABA</scp> inhalers increase phonation threshold pressure (<scp>PTP</scp>) and flow (<scp>PTF</scp>) in rabbits","abstract":"Objectives This study examined the effects of a combination corticosteroid plus long‐acting beta 2 ‐adrenergic agonist inhaler (IC) on rabbit phonation. Methods White New Zealand male rabbits were assigned randomly to experimental and control groups ( n = 11 per group). The experimental group received twice‐daily doses of Advair HFA™ (fluticasone propionate 45 mcg and salmeterol 21 mcg) via a veterinary facemask with 1‐way valve and spacer; the control group received aerosolized saline. After 8 weeks, animals were euthanized, larynges excised, frozen, and subsequently thawed and mounted on a standard bench apparatus. Phonation was elicited during 15 successive trials, and phonation threshold pressure (PTP; cmH 2 O) and flow (PTF; L/min) were quantified. Results Repeated measures analysis of variance indicated significant differences between the experimental and control groups ( p &lt; 0.05). Mean PTP and PTF values were higher (worse) for rabbits that received Advair HFA™. Conclusion Following 8‐week exposure to ICs, rabbit larynges required greater air pressure and flow to initiate phonation. Because even modest phonation onset differences can have a meaningful clinical impact on voice function, these findings suggest that LABA ICs may put patients at risk for voice disorders. Furthermore, these voice disorders may occur within a relatively short timeframe. The results from this study have important clinical implications for voice care in those who use ICs. Level of Evidence NA Laryngoscope , 133:2680–2686, 2023","journal":"The Laryngoscope","year":2023,"id":385907,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9598,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1154267,"name":"Heidi J. Robison","orcid":null,"position":1,"is_corresponding":false},{"id":762399,"name":"Maya Stevens","orcid":"0000-0001-6964-7134","position":2,"is_corresponding":false},{"id":1153882,"name":"Ray M. Merrill","orcid":"0000-0002-4201-0704","position":3,"is_corresponding":false},{"id":1153883,"name":"Christopher Dromey","orcid":"0000-0002-9030-2461","position":4,"is_corresponding":false},{"id":638061,"name":"Julie Barkmeier‐Kraemer","orcid":"0000-0002-5037-3070","position":5,"is_corresponding":false},{"id":974673,"name":"Michael B. Christensen","orcid":"0000-0003-0151-783X","position":6,"is_corresponding":false},{"id":638064,"name":"Kristine Tanner","orcid":"0000-0001-6973-8490","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T01:17:52.636565Z","pmid":"36757019","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}