{"doi":"10.1002/lary.29461","title":"Electrochemical Therapy of In Vivo Rabbit Cutaneous Tissue","abstract":"OBJECTIVES: To examine the acid-base and histological changes in in vivo rabbit cutaneous tissue after electrochemical therapy. STUDY DESIGN: In vivo rabbit tissue study. METHODS: The shaved skin on the backs of female Oryctolagus cuniculi were assigned to treatments with or without tumescence with normal saline. Two platinum-needle electrodes were inserted into each treatment area and connected to a direct current (DC) power supply. Voltage (3-5 V) was varied and applied for 5 minutes. The wound-healing process was monitored via digital photography and ultrasonography until euthanasia at day 29. Treatment areas were biopsied, and specimens were sectioned through a sagittal midline across both electrode insertion sites. Samples were then evaluated utilizing light microscopy (hematoxylin and eosin, Masson's Trichrome, and Picrosirius red). RESULTS: Treatment sites developed mild inflammation that dissipated at lower voltages or became scabs at higher voltages. Ultrasonography demonstrated acoustic shadowing with spatial spread that increased with increasing voltage application. The 4- and 5-V sites treated with saline had localized areas of increased tissue density at day 29. Although specimens treated with 3 V did not look significantly different from control tissue, 4- and 5-V samples with and without saline tumescence had finer, less-organized collagen fibers and increased presence of fibrocytes and inflammatory infiltrates. CONCLUSIONS: Electrochemical therapy caused localized injury to in vivo rabbit cutaneous tissue, prompting regenerative wound repair. With future development, this technology may offer precise, low-cost rejuvenation to restore the functionality and appearance of dermal scars and keloids. LEVEL OF EVIDENCE: NA Laryngoscope, 131:E2196-E2203, 2021.","journal":"The Laryngoscope","year":2021,"id":211683,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.957,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":517447,"name":"Tiffany Pham","orcid":"0000-0002-0308-4540","position":1,"is_corresponding":false},{"id":801111,"name":"Soo Hong Seo","orcid":"0000-0002-3836-0445","position":2,"is_corresponding":false},{"id":517449,"name":"Wesley J. Moy","orcid":"0000-0002-6271-803X","position":3,"is_corresponding":false},{"id":518308,"name":"Pamela A. Borden","orcid":null,"position":4,"is_corresponding":false},{"id":518309,"name":"Kyle D. Hansen","orcid":null,"position":5,"is_corresponding":false},{"id":517454,"name":"Sehwan Kim","orcid":"0000-0002-5491-3732","position":6,"is_corresponding":false},{"id":517453,"name":"Ji‐Hun Mo","orcid":"0000-0003-1331-364X","position":7,"is_corresponding":false},{"id":517456,"name":"Brian J. F. Wong","orcid":"0000-0001-6318-7384","position":8,"is_corresponding":false},{"id":517448,"name":"Ellen M. Hong","orcid":"0000-0002-0084-2924","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-18T23:52:20.112538Z","pmid":"33666252","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}