{"doi":"10.1002/jum.16608","title":"Inter‐Reader Agreement for Contrast‐Enhanced Ultrasound Liver Imaging Reporting and Data System Major Features and Final Categorization","abstract":"OBJECTIVES: Contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI-RADS) is used to definitively diagnose hepatocellular carcinoma (HCC) in patients at risk. However, the user variability associated with CEUS LI-RADS has not been validated in North American and European patients. This study aims to evaluate the inter-reader agreements of CEUS LI-RADS features for, and final categorization of, HCC in patients at risk. METHODS: This retrospective multicenter clinical study used the database of a previous prospective multinational study, evaluating the accuracy of CEUS LI-RADS for HCC diagnosis in patients at risk. All cases were first evaluated by a site physician performing/supervising the CEUS examination. Randomly selected cases were re-evaluated by a blinded central reader. Final diagnosis was confirmed with the reference standard, which was a composite of imaging tests and histology. Cohen's kappa test was used to evaluate inter-reader agreement. RESULTS: This study included 150 liver nodules and 58.0% (87/150) were confirmed as HCC, 4.7% (7/150) non-HCC malignancies, 22.7% (34/150) had no confirmed final diagnosis, and 14.7% (22/150) were nonmalignant. Inter-reader agreements were substantial for CEUS LI-RADS categorization (κ = 0.61; 95% confidence interval [CI]: 0.51-0.71) and major features assessment (ranged κ = 0.64-0.78), LR-5 (κ = 0.65; 95% CI: 0.52-0.77), and LR-M (κ = 0.67; 95% CI: 0.44-0.90), while for LR-1 and LR-2 categorization was almost perfect (κ = 0.85; 95% CI: 0.65-1.00). CONCLUSION: Our study reported a substantial inter-reader agreement for overall CEUS LI-RADS categorization, especially for LR-5 and LR-M, and major imaging features of HCC, further confirming CEUS LI-RADS as a valuable and reliable tool for diagnosis of HCC.","journal":"Journal of Ultrasound in Medicine","year":2024,"id":474368,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9464,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1252549,"name":"Tania Siu Xiao","orcid":"0000-0002-3867-3601","position":1,"is_corresponding":false},{"id":839306,"name":"Yuko Kono","orcid":"0000-0002-9357-4104","position":2,"is_corresponding":false},{"id":748695,"name":"Fabio Piscaglia","orcid":"0000-0001-8264-1845","position":3,"is_corresponding":false},{"id":945080,"name":"Stephanie R. Wilson","orcid":"0000-0001-6396-7612","position":4,"is_corresponding":false},{"id":1248655,"name":"Alexandra Medellin","orcid":"0000-0003-3177-5266","position":5,"is_corresponding":false},{"id":510578,"name":"Shuchi K. Rodgers","orcid":"0000-0003-4280-2960","position":6,"is_corresponding":false},{"id":949092,"name":"Virginia B. Planz","orcid":"0000-0002-8365-2324","position":7,"is_corresponding":false},{"id":382426,"name":"Aya Kamaya","orcid":null,"position":8,"is_corresponding":false},{"id":510579,"name":"David T. Fetzer","orcid":"0000-0002-2420-082X","position":9,"is_corresponding":false},{"id":764284,"name":"Annalisa Berzigotti","orcid":"0000-0003-4562-9016","position":10,"is_corresponding":false},{"id":844311,"name":"Paul S. Sidhu","orcid":"0000-0003-1928-4077","position":11,"is_corresponding":false},{"id":297773,"name":"Corinne E. Wessner","orcid":"0000-0002-5896-3841","position":12,"is_corresponding":false},{"id":297775,"name":"Kristen Bradigan","orcid":"0000-0001-8850-7620","position":13,"is_corresponding":false},{"id":297771,"name":"John R. Eisenbrey","orcid":"0000-0001-6411-3424","position":14,"is_corresponding":false},{"id":297772,"name":"Flemming Forsberg","orcid":"0000-0003-2215-1371","position":15,"is_corresponding":false},{"id":297778,"name":"Andrej Lyshchik","orcid":"0000-0001-8930-2213","position":16,"is_corresponding":false},{"id":1310933,"name":"CEUS LI‐RADS Trial Group","orcid":null,"position":17,"is_corresponding":false},{"id":1310518,"name":"Cristina Kuon-Yeng","orcid":"0000-0003-1089-4952","position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":null,"created_at":"2026-07-19T02:06:09.108857Z","pmid":"39470295","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}