{"doi":"10.1002/jum.16582","title":"Novel Quantitative Liver Steatosis Assessment Method With Ultrasound Harmonic Imaging","abstract":"OBJECTIVES: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent liver disorder in Western countries, with approximately 20%-30% of the MASLD patients progressing to severe stages. There is an urgent need for noninvasive, cost-effective, widely accessible, and precise biomarkers to evaluate liver steatosis. This study aims to assess and compare the diagnostic performance of a novel reference frequency method-based ultrasound attenuation coefficient estimation (ACE) in both fundamental (RFM-ACE-FI) and harmonic (RFM-ACE-HI) imaging for detecting and grading liver steatosis. METHODS: An Institutional Review Board-approved prospective study was carried out between December 2018 and October 2022. A total number of 130 subjects were enrolled in the study. The correlation between RFM-ACE-HI values and magnetic resonance imaging proton density fat fraction (MRI-PDFF), as well as between RFM-ACE-FI values and MRI-PDFF were calculated. The diagnostic performance of RFM-ACE-FI and RFM-ACE-HI was evaluated using receiver operating characteristic (ROC) curve analysis, as compared to MRI-PDFF. The reproducibility of RFM-ACE-HI was assessed by interobserver agreement between two sonographers. RESULTS: A strong correlation was observed between RFM-ACE-HI and MRI-PDFF, with R = 0.88 (95% confidence interval [CI]: 0.83-0.92; P < .001), while the correlation between RFM-ACE-FI and MRI-PDFF was R = 0.65 (95% CI: 0.50-0.76; P < .001). The area under the ROC (AUROC) curve for RFM-ACE-HI in staging liver steatosis grades of S ≥ 1 and S ≥ 2 was 0.97 (95% CI: 0.91-0.99; P < .001) and 0.98 (95% CI: 0.93-1.00; P < .001), respectively, and 0.76 (95% CI: 0.65-0.85) and 0.80 (95% CI: 0.70-0.88) for RFM-ACE-FI, respectively. Great reproducibility was achieved for RFM-ACE-HI, with an interobserver agreement of R = 0.97 (95% CI: 0.94-0.99; P < .001). CONCLUSIONS: The novel RFM-ACE-HI method offered high liver steatosis diagnostic accuracy and reproducibility, which has important clinical implications for early disease intervention and treatment evaluation.","journal":"Journal of Ultrasound in Medicine","year":2024,"id":469275,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9582,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1302630,"name":"Jingke Zhang","orcid":"0000-0003-1916-0541","position":1,"is_corresponding":false},{"id":253782,"name":"Chengwu Huang","orcid":"0000-0003-0745-821X","position":2,"is_corresponding":false},{"id":253789,"name":"U‐Wai Lok","orcid":"0000-0002-4972-8030","position":3,"is_corresponding":false},{"id":253787,"name":"Shanshan Tang","orcid":"0000-0002-1115-6479","position":4,"is_corresponding":false},{"id":1302631,"name":"Hui Liu","orcid":"0000-0002-0207-8173","position":5,"is_corresponding":false},{"id":348381,"name":"Ryan M. DeRuiter","orcid":"0000-0003-2135-6607","position":6,"is_corresponding":false},{"id":1303016,"name":"Kendra E Petersen","orcid":null,"position":7,"is_corresponding":false},{"id":929642,"name":"Kate M Knoll","orcid":"0009-0003-6317-6695","position":8,"is_corresponding":false},{"id":1303017,"name":"Kathryn Robinson","orcid":null,"position":9,"is_corresponding":false},{"id":272304,"name":"Kymberly D. Watt","orcid":"0000-0003-0828-0644","position":10,"is_corresponding":false},{"id":286371,"name":"Matthew R. Callstrom","orcid":"0000-0001-5505-1882","position":11,"is_corresponding":false},{"id":253791,"name":"Shigao Chen","orcid":"0000-0003-3460-127X","position":12,"is_corresponding":false},{"id":253788,"name":"Ping Gong","orcid":"0000-0002-9652-1657","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T02:05:28.027781Z","pmid":"39315751","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}