{"doi":"10.1002/jum.16435","title":"Acoustic Activation Imaging With Intravenous Perfluoropropane Nanodroplets Results in Selective Bioactivation of the Risk Area","abstract":"BACKGROUND: Acoustically activatable perfluoropropane droplets (PD) can be formulated from commercially available microbubble preparations. Diagnostic transthoracic ultrasound frequencies have resulted in acoustic activation (AA) predominately within myocardial infarct zones (IZ). OBJECTIVE: We hypothesized that the AA area following acute coronary ischemia/reperfusion (I/R) would selectively enhance the developing scar zone, and target bioeffects specifically to this region. METHODS: We administered intravenous PD in 36 rats and 20 pigs at various stages of myocardial scar formation (30 minutes, 1 day, and 7 days post I/R) to determine what effect infarct age had on the AA within the IZ. This was correlated with histology, myeloperoxidase activity, and tissue nitrite activity. RESULTS: The degree of AA within the IZ in rats was not associated with collagen content, neutrophil infiltration, or infarct age. AA within 24 hours of I/R was associated with increased nitric oxide utilization selectively within the IZ (P < .05 compared with remote zone). The spatial extent of AA in pigs correlated with infarct size only when performed before sacrifice at 7 days (r = .74, P < .01). CONCLUSIONS: Acoustic activation of intravenous PD enhances the developing scar zone following I/R, and results in selective tissue nitric oxide utilization.","journal":"Journal of Ultrasound in Medicine","year":2024,"id":475488,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9644,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":284306,"name":"Cheng Chen","orcid":"0000-0003-1527-0014","position":1,"is_corresponding":false},{"id":735794,"name":"John Lof","orcid":null,"position":2,"is_corresponding":false},{"id":782223,"name":"Elizabeth Stolze","orcid":null,"position":3,"is_corresponding":false},{"id":782225,"name":"Jiri Sklenar","orcid":null,"position":4,"is_corresponding":false},{"id":364202,"name":"Xucai Chen","orcid":"0000-0001-8621-5261","position":5,"is_corresponding":false},{"id":384382,"name":"John J. Pacella","orcid":null,"position":6,"is_corresponding":false},{"id":364203,"name":"Flordeliza S. Villanueva","orcid":"0000-0003-3980-9176","position":7,"is_corresponding":false},{"id":592934,"name":"Terry O. Matsunaga","orcid":null,"position":8,"is_corresponding":false},{"id":1300881,"name":"E. Carr Everbach","orcid":"0000-0002-7125-939X","position":9,"is_corresponding":false},{"id":609463,"name":"Stanley J. Radio","orcid":null,"position":10,"is_corresponding":false},{"id":1301255,"name":"Sherry Westphal","orcid":null,"position":11,"is_corresponding":false},{"id":106180,"name":"Sruti Shiva","orcid":"0000-0003-3535-2113","position":12,"is_corresponding":false},{"id":1300882,"name":"Feng Xie","orcid":"0000-0003-2457-9275","position":13,"is_corresponding":false},{"id":1300883,"name":"Xiaoping Leng","orcid":"0000-0001-8883-8884","position":14,"is_corresponding":false},{"id":679799,"name":"Thomas R. Porter","orcid":"0000-0003-0881-946X","position":15,"is_corresponding":false},{"id":1301254,"name":"Shouqiang Li","orcid":null,"position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-19T02:06:21.071690Z","pmid":"38440926","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}