{"doi":"10.1002/jum.16190","title":"Follow Your Nose","abstract":"OBJECTIVE: Examine whether repeat nasal bone evaluation following an absent/uncertain nasal bone on first-trimester screening (FTS) improves Down syndrome (DS) screening specificity. METHODS: A retrospective chart review of FTS sonograms in one center from January 2015 to January 2018 was performed. Data was extracted for those with an absent/uncertain nasal bone. Repeat evaluations were offered. RESULTS: Of 6780 FTS sonograms, 589 (8.7%) had an absent/uncertain nasal bone. Upon repeat exam, 268/376 (71.3%) had a present nasal bone. Compared with Black patients, patients of other ethnicities were more likely to have a present nasal bone on exam 2 (P < .00001). Of 268 patients with a present nasal bone on exam 2, 37 (13.8%) had an abnormal DS risk following exam 1; 34/37 (91.9%) normalized following nasal bone visualization, dropping the screen positive rate to 1.1%. CONCLUSION: Repeat nasal bone examination is beneficial in refining DS risk assessment and improves the specificity of FTS.","journal":"Journal of Ultrasound in Medicine","year":2023,"id":353590,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":918542,"name":"Katelynn G. Sagaser","orcid":"0000-0001-9812-771X","position":1,"is_corresponding":false},{"id":918544,"name":"Christine Hertenstein","orcid":"0009-0008-6484-3337","position":2,"is_corresponding":false},{"id":461420,"name":"Karin J. Blakemore","orcid":"0000-0002-5419-4934","position":3,"is_corresponding":false},{"id":918545,"name":"Katherine R. Forster","orcid":"0000-0002-4669-6088","position":4,"is_corresponding":false},{"id":918543,"name":"Cathleen Lawson","orcid":"0000-0003-4162-9852","position":5,"is_corresponding":false},{"id":778515,"name":"Angie C. Jelin","orcid":"0000-0002-1792-4029","position":6,"is_corresponding":false},{"id":918546,"name":"Kristen A. Miller","orcid":"0000-0001-8567-3850","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":null,"created_at":"2026-07-19T01:13:02.680107Z","pmid":"36744578","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}