{"doi":"10.1002/jsp2.70045","title":"Annulus Fibrosus Repair via Interpenetration of a Non‐Woven Scaffold Supports Tissue Integration and Prevents Re‐Herniation","abstract":"Background: Current surgical management of intervertebral disc herniation often fails to adequately address the risk of recurrence, primarily due to the disc's limited regenerative capacity. Regenerative, biomaterial-based approaches for tissue augmentation, while showing preclinical promise, have consistently failed to meet the extreme mechanical demands of the intervertebral disc, impeding their clinical translation. Methods: In this study, we introduce a novel annulus repair strategy that employs the mechanical interpenetration of a non-woven PET scaffold into intervertebral disc tissue to resist reherniation. We investigate the efficacy in preventing herniations under compression using a bovine explant model and validate its performance in a pilot in vivo study in a goat cervical spine injury model. Healing and scaffold integration are assessed over 4 weeks using computed tomography, magnetic resonance imaging, and histopathology. Results: We demonstrate that this approach effectively prevents mechanically induced herniation. In vivo, the scaffold interpenetration enables biological integration at 4 weeks post-surgery, with no evidence of scaffold migration or disc degeneration. The scaffold supports matrix deposition and cell infiltration, with no observed endplate pathologies or osteolysis. Conclusions: These findings highlight a promising combination of biomechanical reliability and favorable histological outcomes, underscoring the potential of this technology for advancing toward human clinical applications.","journal":"JOR Spine","year":2025,"id":520512,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9567,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1132822,"name":"Mohammed A. Abdullah","orcid":null,"position":1,"is_corresponding":false},{"id":305884,"name":"Julie B. Engiles","orcid":"0000-0001-9057-2093","position":2,"is_corresponding":false},{"id":1043885,"name":"Brianna S. Orozco","orcid":"0009-0003-3271-2678","position":3,"is_corresponding":false},{"id":1390054,"name":"Andrea Moehl","orcid":"0009-0002-5657-4727","position":4,"is_corresponding":false},{"id":293038,"name":"Ana P. Peredo","orcid":"0000-0001-8383-039X","position":5,"is_corresponding":false},{"id":1120864,"name":"Sonal Mahindroo","orcid":"0000-0002-2916-1022","position":6,"is_corresponding":false},{"id":1285754,"name":"Rachel Hilliard","orcid":null,"position":7,"is_corresponding":false},{"id":456215,"name":"Thomas P. Schaer","orcid":"0000-0002-4340-8212","position":8,"is_corresponding":false},{"id":284005,"name":"Robert L. Mauck","orcid":"0000-0002-9537-603X","position":9,"is_corresponding":false},{"id":284006,"name":"Harvey E. Smith","orcid":"0000-0003-0488-2541","position":10,"is_corresponding":false},{"id":738418,"name":"Mazda Farshad","orcid":"0000-0002-7190-1127","position":11,"is_corresponding":false},{"id":691286,"name":"Jess G. Snedeker","orcid":"0000-0002-8115-0275","position":12,"is_corresponding":false},{"id":284007,"name":"Sarah E. Gullbrand","orcid":"0000-0001-7806-6606","position":13,"is_corresponding":false},{"id":1390053,"name":"E. Ongini","orcid":"0009-0005-9091-4483","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T02:49:28.470782Z","pmid":"39925750","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}