{"doi":"10.1002/jso.27412","title":"High‐dose IV magnesium in mesothelioma patients receiving surgery with hyperthermic intraoperative cisplatin: Pilot studies and design of a phase II randomized clinical trial","abstract":"INTRODUCTION: Hyperthermic intraoperative cisplatin (HIOC) is associated with acute kidney injury (AKI). Administration of high-dose magnesium attenuates cisplatin-induced AKI (CP-AKI) in animal models but has not been rigorously examined in humans. METHODS: We tested the feasibility and safety of different doses of magnesium in mesothelioma patients receiving HIOC. In Pilot Study 1, we administered a 36-h continuous infusion of magnesium at 0.5 g/h, targeting serum magnesium levels between 3 and 4.8 mg/dL. In Pilot Study 2A, we administered a 6 g bolus followed by an infusion starting at 2 g/h, titrated to achieve levels between 4 and 6 mg/dL. We eliminated the bolus in Pilot Study 2B. RESULTS: In Pilot Study 1, all five patients enrolled completed the study; however, median postoperative Mg levels were only 2.4 mg/dL. In Pilot Study 2A, two of four patients (50%) were withdrawn due to bradycardia during the bolus. In Pilot Study 2B, two patients completed the study whereas two developed postoperative bradycardia attributed to the magnesium. CONCLUSIONS: A 0.5 g/h infusion for 36 h did not achieve therapeutic magnesium levels, while an infusion at 2 g/h was associated with bradycardia. These studies informed the design of a randomized clinical trial testing whether intravenously Mg attenuates HIOC-associated AKI.","journal":"Journal of Surgical Oncology","year":2023,"id":382433,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9556,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1084418,"name":"Sophia L. Wells","orcid":null,"position":1,"is_corresponding":false},{"id":1148931,"name":"Arunima M. Jose","orcid":null,"position":2,"is_corresponding":false},{"id":1148589,"name":"Robert H. Seitter","orcid":"0009-0006-1212-0407","position":3,"is_corresponding":false},{"id":1068461,"name":"Lea Feghali","orcid":"0000-0003-4592-5958","position":4,"is_corresponding":false},{"id":1148932,"name":"Nishant Devaraj","orcid":null,"position":5,"is_corresponding":false},{"id":1148590,"name":"Philip M. Hartigan","orcid":"0000-0001-6543-4385","position":6,"is_corresponding":false},{"id":1148933,"name":"Stephanie Yacoubian","orcid":null,"position":7,"is_corresponding":false},{"id":298782,"name":"David J. Kwiatkowski","orcid":"0000-0002-5668-5219","position":8,"is_corresponding":false},{"id":1148934,"name":"Donna M. Burke","orcid":null,"position":9,"is_corresponding":false},{"id":1148591,"name":"Julianne Barlow","orcid":"0009-0008-3443-4276","position":10,"is_corresponding":false},{"id":38311,"name":"Raphael Bueno","orcid":"0000-0002-3231-5491","position":11,"is_corresponding":false},{"id":140241,"name":"David E. Leaf","orcid":"0000-0001-7875-090X","position":12,"is_corresponding":false},{"id":108943,"name":"Shruti Gupta","orcid":"0000-0002-5747-2151","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T01:17:17.113710Z","pmid":"37702402","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}