{"doi":"10.1002/jso.25984","title":"Impact of tumor regression grade on recurrence after preoperative chemoradiation and gastrectomy for gastric cancer","abstract":"BACKGROUND AND OBJECTIVES: It is unknown whether the degree of response to preoperative therapy correlates with locoregional recurrence (LR) or distant recurrence (DR) after resection of gastric cancer. METHODS: Patients who underwent resection of gastric adenocarcinoma following chemotherapy and chemoradiation (1995-2015) were reviewed. The tumor regression grade (TRG) was defined by the percentage of viable tumor cells in the specimen (TRG0 = 0%; TRG1 = 1%-2%; TRG2 = 3%-50%; TRG3 ≥ 50%). The relationships among TRG, recurrence-free survival (RFS), LR, and DR were examined. RESULTS: Two hundred forty-seven patients met the inclusion criteria (TRG0, 52 [21%]; TRG1, 49 [20%]; TRG2, 98 [40%]; TRG3, 48 [19%]). LR and DR occurred in 6.1% and 32.0% of patients, respectively. No patient with TRG0 experienced LR. R1 resection (6%-15%) and LR (6%-8%) rates were similar among TRG1-3 patients. R1 resection was associated with LR (hazard ratio [HR], 17.85; P < .001). ypN status (HR, 2.44; P = .004) and linitis plastica (HR, 2.90; P < .001) were associated with DR. TRG was not independently associated with RFS, LR, or DR. CONCLUSIONS: TRG0 imparted excellent local control. However, TRG1-3 patients had similar R1 resection rates and therefore similar LR. DR is associated with ypN status and linitis plastica, not TRG.","journal":"Journal of Surgical Oncology","year":2020,"id":64648,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9555,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":341837,"name":"Jeannelyn S. Estrella","orcid":"0000-0003-3705-5964","position":1,"is_corresponding":false},{"id":343238,"name":"Yi‐Ju Chiang","orcid":null,"position":2,"is_corresponding":false},{"id":341838,"name":"Prajnan Das","orcid":"0000-0002-3845-0707","position":3,"is_corresponding":false},{"id":72433,"name":"Bruce D. Minsky","orcid":"0000-0001-8434-7930","position":4,"is_corresponding":false},{"id":343239,"name":"Mariela A. Blum Murphy","orcid":null,"position":5,"is_corresponding":false},{"id":69924,"name":"Jaffer A. Ajani","orcid":"0000-0001-9946-0629","position":6,"is_corresponding":false},{"id":343240,"name":"Paul Mansfield","orcid":null,"position":7,"is_corresponding":false},{"id":341839,"name":"Brian D. Badgwell","orcid":"0000-0002-9915-8355","position":8,"is_corresponding":false},{"id":341840,"name":"Naruhiko Ikoma","orcid":"0000-0002-9825-9234","position":9,"is_corresponding":false},{"id":341836,"name":"Alexander P. Stark","orcid":"0000-0001-8463-5414","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-18T21:12:58.081635Z","pmid":"32462681","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}