{"doi":"10.1002/jps.20324","title":"Nuclear Receptors and Drug Disposition Gene Regulation","abstract":null,"journal":"Journal of Pharmaceutical Sciences","year":2005,"id":590375,"datarank":8.20681857809747,"base_score":5.2574953720277815,"endowment":5.2574953720277815,"self_citation_contribution":0.7886243058041673,"citation_network_contribution":7.418194272293303,"self_endowment_contribution":0.7886243058041673,"citer_contribution":7.418194272293303,"corpus_percentile":null,"corpus_rank":null,"citation_count":191,"citer_count":183,"citers_with_citation_signal":171,"citers_with_endowment":171,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1181546,"name":"Richard B. 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Specifically, the molecular aspects and functional impact of the aryl hydrocarbon receptor (AhR), nuclear factor-E2 p45-related factor 2 (N(r)f2), hepatocyte nuclear factor 1alpha (HNF1alpha), constitutive androstane receptor (LAR), pregnane X receptor (PXR), farnesoid X receptor (FXR), peroxisome proliferator-activated receptor alpha (PPAR(alpha)), hepatocyte nuclear factor 4alpha (HNF4alpha), vitamin D receptor (VDR), liver receptor homolog 1 (LRH1), liver X receptor (LXR(alpha)), small heterodimer partner-1 (SHP-1), and glucocorticoid receptor (GR) on gene expression are detailed. Finally, we discuss some current topics and themes in nuclear receptor-mediated regulation of drug metabolizing enzymes and drug transporters.","is_dataset_classified":null,"base_score":5.2574953720277815,"endowment":5.2574953720277815,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15858847","pmcid":null,"openalex_id":"https://openalex.org/W1998622278","authors":[],"funders":[],"total_grants":0,"fwci":20.8834,"citation_percentile":0.9963001,"influential_citations":0,"citation_trend":[{"year":2012,"count":13},{"year":2013,"count":13},{"year":2014,"count":9},{"year":2015,"count":14},{"year":2016,"count":9},{"year":2017,"count":7},{"year":2018,"count":2},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":2},{"year":2022,"count":6},{"year":2023,"count":3},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0022354916317877?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022354916317877?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1002/jps.20324","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15858847","host_type":"repository"}],"fields_of_study":["Pharmacogenetics and Drug Metabolism","Drug Transport and Resistance Mechanisms","Hormonal Regulation and Hypertension","Animals","DNA-Binding Proteins","Flavoproteins","Gene Expression Regulation","Hepatocyte Nuclear Factor 4","Humans","NF-E2-Related Factor 2","Oxidoreductases","PPAR alpha","Pharmaceutical Preparations","Phosphoproteins","Receptors, Cytoplasmic and Nuclear","Trans-Activators","Transcription Factors","Transcription, Genetic","Receptor, Farnesoid X-Activated"],"mesh_terms":["Receptor, Farnesoid X-Activated","Animals","DNA-Binding Proteins","Pharmaceutical Preparations","Flavoproteins","Gene Expression Regulation","Humans","Oxidoreductases","Phosphoproteins","Transcription Factors","Transcription, Genetic","Trans-Activators","Receptors, Cytoplasmic and Nuclear","PPAR alpha","NF-E2-Related Factor 2","Hepatocyte Nuclear Factor 4"],"keywords":["Pregnane X receptor","Constitutive androstane receptor","Nuclear receptor","Liver receptor homolog-1","Hepatocyte nuclear factor 4","Estrogen-related receptor gamma","Aryl hydrocarbon receptor","Farnesoid X receptor","Small heterodimer partner","Calcitriol receptor","Hepatocyte nuclear factors","Liver X receptor alpha","Nuclear receptor coactivator 2","Nuclear receptor coactivator 1","Glucocorticoid receptor","Nuclear receptor co-repressor 1","Liver X receptor","Peroxisome proliferator-activated receptor","Biology","Interleukin-21 receptor","Transcription factor","Receptor","Biochemistry","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-24T19:12:20.361774Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}