{"doi":"10.1002/jpr3.70119","title":"Autoantibody signatures in children with celiac disease, juvenile idiopathic arthritis, and polyautoimmunity","abstract":"Objective: To determine if multiplex autoantibody arrays can identify novel biomarker signatures in children with one or multiple autoimmune diseases (polyautoimmunity). Methods: Plasma collected from children (18 years or younger) in the Boston Children's Hospital Precision Link Biobank for Health Discovery between January 2007 and June 2021 was analyzed using a microarray with 120 autoantigens associated with various autoimmune diseases to assess for both immunoglobulin G (IgG) and A (IgA) autoantibodies. To determine if disease-specific, we binary classified those with polyautoimmunity and the most common autoimmune diseases in our cohort (autoimmune thyroid disease, type 1 diabetes, or celiac disease [CeD]). For each comparison within and between groups, the autoantibody intensity was releveled to the control and a linear model was fit. Results: = 32). Overall, children with polyautoimmunity had higher levels of specific autoantibodies relative to the other groups. Children with CeD and polyautoimmunity expressed higher levels of H/K ATPase IgA and IgG and MDA5 IgG compared to those with CeD alone. Conclusions: Use of multiplex antigen arrays in patients with and without polyautoimmunity is a valuable tool to identify known and potentially novel disease-antigens. Further study is needed to determine the role of H/K ATPase autoantibodies in monitoring of CeD patients.","journal":"JPGN Reports","year":2025,"id":529404,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.935,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":760830,"name":"Denis Chang","orcid":"0000-0002-3843-5785","position":1,"is_corresponding":false},{"id":1408678,"name":"Madison Wong","orcid":null,"position":2,"is_corresponding":false},{"id":60543,"name":"Jay R. Thiagarajah","orcid":"0000-0002-1437-325X","position":3,"is_corresponding":false},{"id":230142,"name":"Erin Janssen","orcid":"0000-0002-0687-2550","position":4,"is_corresponding":false},{"id":230130,"name":"Lauren A. Henderson","orcid":"0000-0003-0242-4029","position":5,"is_corresponding":false},{"id":298133,"name":"Krishnan Raghunathan","orcid":"0000-0003-2228-6313","position":6,"is_corresponding":false},{"id":281001,"name":"Jocelyn A. Silvester","orcid":"0000-0002-3615-1666","position":7,"is_corresponding":false},{"id":798930,"name":"Nan Du","orcid":"0000-0002-2728-917X","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-19T02:50:56.971987Z","pmid":"41695077","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}