{"doi":"10.1002/jpn3.70135","title":"Acute pancreatitis gut dysbiosis persists at 1‐year follow‐up and is associated with clinical outcomes","abstract":"OBJECTIVES: Pediatric acute pancreatitis (AP) is associated with gut dysbiosis. We aimed to determine if dysbiosis persisted during follow-up and whether it is associated with clinical outcomes. METHODS: Prospective enrollment of participants <21 years with first AP. Stool samples were obtained at baseline (n = 41), 3 months (n = 19), and 12 months (n = 12) and in healthy controls (HC; n = 34). Evaluation for diabetes (DM) or prediabetes (pre-DM) was performed. At 12-month follow-up gastrointestinal (GI) symptom surveys were completed and AP recurrence-acute recurrent pancreatitis (ARP) recorded. Shotgun metagenomic sequencing was performed on extracted microbial DNA. RESULTS: Microbial alpha diversity was lower for AP versus HC at all three time points (p < 0.008). Bray-Curtis ordinations showed the AP cohort did not cluster by time point, highlighting similarity in microbial composition over time. Within 12-month follow-up: 7/44 participants developed pre-DM/DM, 7/42 developed ARP, 16 had zero or one while 15 had multiple GI symptoms. Distinct clustering of samples was observed in the baseline samples of the group that developed ARP (p = 0.023) and in follow-up samples with multiple GI symptoms, p < 0.05. Relative abundance of most species was lower in AP samples when compared to HC at all time points with enrichment in Ruminococcus gnavus and Clostridium innocuum (AQ) (False Discovery Rate p < 0.05). Several pathways involved in protein biosynthesis were depleted in the AP cohort at all time points. CONCLUSIONS: Gut dysbiosis persisted following AP in children at 3 and 12 months follow-up compared to HC. Microbiome signatures differed in the ARP cohort and those with multiple GI symptoms.","journal":"Journal of Pediatric Gastroenterology and Nutrition","year":2025,"id":553385,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8216,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":599720,"name":"Qing Duan","orcid":"0009-0002-5748-9065","position":1,"is_corresponding":false},{"id":1450017,"name":"Faizan Ahmed","orcid":"0000-0002-9839-7039","position":2,"is_corresponding":false},{"id":291505,"name":"Lee A. Denson","orcid":"0000-0001-8045-7198","position":3,"is_corresponding":false},{"id":302643,"name":"David Haslam","orcid":"0000-0002-2143-5869","position":4,"is_corresponding":false},{"id":1450408,"name":"Philip Minar","orcid":null,"position":5,"is_corresponding":false},{"id":482479,"name":"Nicholas J. Ollberding","orcid":"0000-0001-9404-7368","position":6,"is_corresponding":false},{"id":371643,"name":"Georgios I. Papachristou","orcid":"0000-0001-9915-703X","position":7,"is_corresponding":false},{"id":526807,"name":"Kenneth D.R. Setchell","orcid":"0000-0001-9147-0136","position":8,"is_corresponding":false},{"id":470036,"name":"Tyler Thompson","orcid":"0009-0009-7061-6664","position":9,"is_corresponding":false},{"id":470037,"name":"David S. Vitale","orcid":"0000-0002-8994-7940","position":10,"is_corresponding":false},{"id":705206,"name":"Xueheng Zhao","orcid":"0000-0002-4156-3294","position":11,"is_corresponding":false},{"id":368883,"name":"Maisam Abu‐El‐Haija","orcid":"0000-0002-8968-7851","position":12,"is_corresponding":false},{"id":368870,"name":"Chinenye R. Dike","orcid":"0000-0003-2435-3655","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T02:54:41.819682Z","pmid":"40600350","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}