{"doi":"10.1002/jor.25537","title":"Acute bone loss following SARS‐CoV‐2 infection in mice","abstract":"<jats:title>Abstract</jats:title><jats:p>The novel coronavirus disease 2019 (COVID‐19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and has infected more than 650 million people worldwide. Approximately 23% of these patients developed lasting “long‐haul” COVID symptoms, including fatigue, joint pain, and systemic hyperinflammation. However, the direct clinical impact of SARS‐CoV‐2 infection on the skeletal system including bone and joint health has not been determined. Utilizing a humanized mouse model of COVID‐19, this study provides the first direct evidence that SARS‐CoV‐2 infection leads to acute bone loss, increased osteoclast number, and thinner growth plates. This bone loss could decrease whole‐bone mechanical strength and increase the risk of fragility fractures, particularly in older patients, while thinner growth plates may create growth disturbances in younger patients. Evaluating skeletal health in patients that have recovered from COVID‐19 will be crucial to identify at‐risk populations and develop effective countermeasures.</jats:p>","journal":"Journal of Orthopaedic Research","year":2023,"id":623261,"datarank":0.4943755299006494,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.0,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":293998,"name":"Bernd Christiansen","orcid":"0000-0002-0105-6458","position":1,"is_corresponding":false},{"id":1307388,"name":"Sophie Orr","orcid":"0000-0003-4315-9014","position":2,"is_corresponding":false},{"id":407471,"name":"Erin E. 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This bone loss could decrease whole‐bone mechanical strength and increase the risk of fragility fractures, particularly in older patients, while thinner growth plates may create growth disturbances in younger patients. Evaluating skeletal health in patients that have recovered from COVID‐19 will be crucial to identify at‐risk populations and develop effective countermeasures.</jats:p>","is_dataset_classified":null,"base_score":3.295836866004329,"endowment":3.295836866004329,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36815216","pmcid":"PMC10440245","openalex_id":"https://openalex.org/W4321599768","authors":[],"funders":[{"funder_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","grant_id":"AR071459 (BAC)","title":null},{"funder_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","grant_id":"AR075013 (BAC)","title":null},{"funder_name":"NIAMS NIH HHS","grant_id":"R01 AR071459","title":null},{"funder_name":"NIAMS NIH HHS","grant_id":"T32 AR079099","title":null},{"funder_name":"NIAMS NIH HHS","grant_id":"R01 AR075013","title":null}],"total_grants":5,"fwci":4.2538,"citation_percentile":0.95296829,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":3},{"year":2024,"count":11},{"year":2025,"count":9},{"year":2026,"count":2}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.25537","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.25537","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/jor.25537","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jor.25537","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/am-pdf/10.1002/jor.25537","host_type":"publisher"},{"url":"https://doi.org/10.1002/jor.25537","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36815216","host_type":"repository"},{"url":"https://escholarship.org/uc/item/5f38v74w","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10440245","host_type":"repository"},{"url":"https://escholarship.org/content/qt5f38v74w/qt5f38v74w.pdf","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10440245/pdf/nihms-1878285.pdf","host_type":"repository"}],"fields_of_study":["COVID-19 Clinical Research Studies","Long-Term Effects of COVID-19","Dermatological and COVID-19 studies"],"mesh_terms":["COVID-19","SARS-CoV-2","Post-Acute COVID-19 Syndrome","Animals","Bone Diseases, Metabolic","Mice"],"keywords":["Medicine","Coronavirus disease 2019 (COVID-19)","Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","Osteoclast","Coronavirus","Fragility","Disease","Immunology","Internal medicine","Infectious disease (medical specialty)","Osteoclasts","growth plate","Covid-19","Sars-cov-2","Postacute Covid-19 Syndrome"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T23:01:27.146557Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}