{"doi":"10.1002/jor.24853","title":"Alendronate enhances osseointegration in a murine implant model","abstract":"Administration of bisphosphonates following total joint arthroplasty might be beneficial to reduce aseptic loosening. However, their effects on peri-implant bone formation and bone-implant interface strength have not been investigated yet. We used a physiologically loaded mouse implant model to investigate the short-term effects of postoperative systemic alendronate on osseointegration. A titanium implant with a rough surface was inserted in the proximal tibiae of 17-week-old female C57BL/6 mice (n = 44). Postimplantation mice were given alendronate (73 μg/kg/days, n = 22) or vehicle (n = 22) 5 days/week. At 7- and 14-day postimplantation, histology and histomorphometry were conducted. At 28 days, microcomputed tomography and biomechanical testing were performed (n = 10/group). Postoperative alendronate treatment enhanced osseointegration, increasing maximum pullout load by 45% (p < .001) from 19.1 ± 4.5 N in the control mice to 27.6 ± 4.9 N in the treated mice, at day 28 postimplantation. Alendronate treatment increased the bone volume fraction by 139% (p < .001) in the region distal to the implant and 60% (p < .05) in the peri-implant region. At 14-day postimplantation, alendronate treatment decreased the number of osteoclasts per bone perimeter (p < .05) and increased bone volume fraction (p < .01) when compared with the control group. Postimplantation, short-term alendronate treatment enhanced osseointegration as demonstrated by increased bone mass, trabecular bone thickness, and maximum pullout load. Alendronate decreased peri-implant osteoclasts while preserving peri-implant osteoblasts and endothelial cells, in turn, increasing bone volume fraction. This data supports the postoperative clinical use of bisphosphonates, especially in patients with high risks of aseptic loosening.","journal":"Journal of Orthopaedic Research®","year":2020,"id":76504,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9569,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":399238,"name":"Branden Sosa","orcid":"0000-0002-1054-2917","position":1,"is_corresponding":false},{"id":383409,"name":"Yingzhen Niu","orcid":"0000-0003-0058-7254","position":2,"is_corresponding":false},{"id":399239,"name":"Gang Ji","orcid":"0000-0001-8535-2635","position":3,"is_corresponding":false},{"id":399240,"name":"Vincentius J. Suhardi","orcid":"0000-0002-5783-5434","position":4,"is_corresponding":false},{"id":383408,"name":"Kathleen Turajane","orcid":"0000-0001-6018-0961","position":5,"is_corresponding":false},{"id":239976,"name":"Se Hwan Mun","orcid":"0000-0002-8218-8531","position":6,"is_corresponding":false},{"id":282927,"name":"Ren Xu","orcid":"0000-0001-6578-4553","position":7,"is_corresponding":false},{"id":399241,"name":"Reinhard Windhager","orcid":"0000-0002-6321-1804","position":8,"is_corresponding":false},{"id":400789,"name":"Kyung Hyun Park‐Min","orcid":null,"position":9,"is_corresponding":false},{"id":106894,"name":"Matthew B. Greenblatt","orcid":"0000-0001-9794-8532","position":10,"is_corresponding":false},{"id":383411,"name":"Mathias P. Bostrom","orcid":"0000-0003-0906-7554","position":11,"is_corresponding":false},{"id":383412,"name":"Xu Yang","orcid":"0000-0001-8377-077X","position":12,"is_corresponding":false},{"id":399237,"name":"Klemens Vertesich","orcid":"0000-0002-9816-8471","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-18T21:48:27.511277Z","pmid":"32915488","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}