{"doi":"10.1002/jnr.490190302","title":"Angiotensinogen gene expression in neuronal and glial cells in primary cultures of rat brain","abstract":"<jats:title>Abstract</jats:title><jats:p>Neuronal and glial cells in primary culture prepared from the hypothalamic‐brain stem areas of one‐day‐old rat brain were analyzed for the presence of angiotensinogen messenger RNA (mRNA) to further confirm our previous conclusion that the brain contains an exclusive angiotensin system. Angiotensinogen mRNA was quantitated by Northern analysis using nick‐translated angiotensinogen cDNA as the hybirdization probe (Kunapuli and Kumar, 1987). Angiotensinogen mRNA sequences were present in the RNA isolated from both neuronal and glial cultures. Quantitative measurements of the mRNA using dot‐blot analysis revealed that the level of angiotensinogen mRNA was three times higher in neuronal cultures compared with glial cultures. These observations provide the first evidence for the synthesis of angiotensinogen in neuronal as well as in glial cells form the brain.</jats:p>","journal":"Journal of Neuroscience Research","year":1988,"id":15376,"datarank":3.3310594406999483,"base_score":4.127134385045092,"endowment":4.127134385045092,"self_citation_contribution":0.6190701577567639,"citation_network_contribution":2.7119892829431844,"self_endowment_contribution":0.6190701577567639,"citer_contribution":2.7119892829431844,"corpus_percentile":null,"corpus_rank":null,"citation_count":61,"citer_count":53,"citers_with_citation_signal":51,"citers_with_endowment":51,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":117552,"name":"A. Rassoli","orcid":null,"position":1,"is_corresponding":false},{"id":117553,"name":"M. K. Raizada","orcid":null,"position":2,"is_corresponding":false},{"id":46383,"name":"A. Kumar","orcid":"0000-0002-8477-9079","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.127134385045092,"endowment":4.127134385045092,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"3379645","pmcid":null,"openalex_id":"https://openalex.org/W2092145250","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"HL 33610","title":null}],"total_grants":1,"fwci":0.8678,"citation_percentile":0.73774141,"influential_citations":1,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":2},{"year":2014,"count":3},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2017,"count":2},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":4}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjnr.490190302","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/jnr.490190302","host_type":"publisher"},{"url":"https://doi.org/10.1002/jnr.490190302","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/3379645","host_type":"repository"}],"fields_of_study":["Receptor Mechanisms and Signaling","Renin-Angiotensin System Studies","Neuropeptides and Animal Physiology","Medicine","Biology","Angiotensinogen","Animals","Animals, Newborn","Brain","Cells, Cultured","DNA","Genes","Liver","Neuroglia","Neurons","RNA, Messenger","Rats","Rats, Inbred WKY","Transcription, Genetic"],"mesh_terms":["Angiotensinogen","Animals","Animals, Newborn","Brain","Cells, Cultured","DNA","Genes","Liver","Neuroglia","Neurons","Rats, Inbred WKY","RNA, Messenger","Transcription, Genetic","Rats"],"keywords":["Northern blot","Messenger RNA","Biology","Complementary DNA","Molecular biology","Dot blot","Gene expression","Neuroglia","RNA","Cell culture","Gene","Central nervous system","Endocrinology","Genetics"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.26719791.v1","title":"Additional file 1 of Characterizing dysregulations via cell-cell communications in Alzheimer’s brains using single-cell transcriptomes","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26719791","title":"Additional file 1 of Characterizing dysregulations via cell-cell communications in Alzheimer’s brains using single-cell transcriptomes","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T17:28:18.959086Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}