{"doi":"10.1002/jnr.1084","title":"Endogenous IGF1 enhances cell survival in the postnatal dentate gyrus","abstract":"<jats:title>Abstract</jats:title><jats:p>The dentate gyrus is selectively reduced in size in the insulin‐like growth factor 1 (<jats:italic>IGF1</jats:italic>) null mouse brain. The purpose of this study was to determine whether this defect is due to reduced granule cell numbers, and if so, to determine whether altered cell proliferation, survival, or both contribute to attenuation of dentate gyrus size. At postnatal day 10 (P10), granule cell numbers were not significantly different in <jats:italic>IGF1</jats:italic> null and littermate wildtype (WT) dentate gyri. The subgranular zone cell population, however, was relatively increased, and the granule cell layer population relatively decreased in the <jats:italic>IGF1</jats:italic> null dentate gyrus. By P50, total dentate cell numbers were decreased by 20% (<jats:italic>P</jats:italic> = 0.01) in the <jats:italic>IGF1</jats:italic> null mouse, although <jats:italic>IGF1</jats:italic> null subgranular zone progenitor cells remained relatively increased compared with WT (38%, <jats:italic>P</jats:italic> &lt; 0.05). <jats:italic>IGF1</jats:italic> null dentate cell proliferation, assessed by thymidine analogue incorporation, was actually increased at P10 (33%, <jats:italic>P</jats:italic> &lt; 0.05) and P50 (167%, <jats:italic>P</jats:italic> = 0.001). Dentate granule cell death, assessed by the appearance of pycnotic cells and DNA fragmentation, was also significantly increased in the <jats:italic>IGF1</jats:italic> null dentate (61%, <jats:italic>P</jats:italic> &lt; 0.05 and 101%, <jats:italic>P</jats:italic> = 0.03). These data suggest that endogenous IGF1 serves an important role in dentate granule cell survival during the course of postnatal brain development. In addition, this work suggests the potential of a compensatory mechanism promoting increased dentate cell proliferation in the face of impaired cell survival during postnatal neurogenesis. J. Neurosci. Res. 64:341–347, 2001. Published 2001 Wiley‐Liss, Inc.</jats:p>","journal":"Journal of Neuroscience Research","year":2001,"id":637978,"datarank":0.6515708132780527,"base_score":4.343805421853684,"endowment":4.343805421853684,"self_citation_contribution":0.6515708132780527,"citation_network_contribution":0.0,"self_endowment_contribution":0.6515708132780527,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":76,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1656797,"name":"Matt Cohen","orcid":null,"position":1,"is_corresponding":false},{"id":481165,"name":"Victor Tseng","orcid":"0000-0003-1380-2240","position":2,"is_corresponding":false},{"id":1656799,"name":"Carolyn A. 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The subgranular zone cell population, however, was relatively increased, and the granule cell layer population relatively decreased in the <jats:italic>IGF1</jats:italic> null dentate gyrus. By P50, total dentate cell numbers were decreased by 20% (<jats:italic>P</jats:italic> = 0.01) in the <jats:italic>IGF1</jats:italic> null mouse, although <jats:italic>IGF1</jats:italic> null subgranular zone progenitor cells remained relatively increased compared with WT (38%, <jats:italic>P</jats:italic> &lt; 0.05). <jats:italic>IGF1</jats:italic> null dentate cell proliferation, assessed by thymidine analogue incorporation, was actually increased at P10 (33%, <jats:italic>P</jats:italic> &lt; 0.05) and P50 (167%, <jats:italic>P</jats:italic> = 0.001). Dentate granule cell death, assessed by the appearance of pycnotic cells and DNA fragmentation, was also significantly increased in the <jats:italic>IGF1</jats:italic> null dentate (61%, <jats:italic>P</jats:italic> &lt; 0.05 and 101%, <jats:italic>P</jats:italic> = 0.03). These data suggest that endogenous IGF1 serves an important role in dentate granule cell survival during the course of postnatal brain development. In addition, this work suggests the potential of a compensatory mechanism promoting increased dentate cell proliferation in the face of impaired cell survival during postnatal neurogenesis. J. Neurosci. Res. 64:341–347, 2001. 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